UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 14A

PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE

SECURITIES EXCHANGE ACT OF 1934

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AVANIR PHARMACEUTICALS, INC.

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LOGO


(AVANIR LOGO)
10120 Enterprise, Suite 300
200

Aliso Viejo, California 92656

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

To Be Held on February 18, 201016, 2012

Dear Stockholder:

You are cordially invited to attend the Annual Meeting of Stockholders of Avanir Pharmaceuticals, Inc., a Delaware corporation (the“Company”Company), which will be held on February 18, 2010,16, 2012, at 9:00 a.m. local time, at The Islandthe Renaissance Club Sport Aliso Viejo Hotel, 690 Newport Center Drive, Newport Beach,50 Enterprise, Aliso Viejo, California. Only stockholders who held stock at the close of business on the record date, December 22, 200919, 2011 (theRecord Date”Date), may vote at the Annual Meeting, including any adjournment or postponement.

postponement thereof.

At the Annual Meeting, you will be asked to consider and vote upon: (1) the election of threetwo Class IIIII directors; (2) the ratification of KMJ Corbin & Company, LLP as our independent registered public accounting firm for the fiscal year ending September 30, 20102012, (3) an advisory (non-binding) vote on the Company’s executive compensation and (3)(4) the transaction of any other business that may properly come before the meeting or any adjournment thereof. No other items of business are expected to be considered at the meeting and no other director nominees will be entertained, pursuant to the Company’s Bylaws.

The accompanying Proxy Statement more fully describes the details of the business to be conducted at the Annual Meeting. After careful consideration, our Board of Directors has unanimously approved the proposals and recommends that you vote FOR each nominee and proposal described in the Proxy Statement.

We are pleased to make use of the Securities and Exchange Commission rules that allow issuerscompanies to furnish proxy materials to their stockholders via the Internet. We believe the ability to deliver proxy materials electronically allows us to provide our stockholders with the information they need, while lowering the costs of delivery and reducing the environmental impact from the distribution of our Annual Meeting materials.

We look forward to seeing you at the Annual Meeting.

Sincerely,

-s- Keith A. Katkin

LOGO

Keith A. Katkin

President and Chief Executive Officer

December 28, 2009

21, 2011

I M P O R T A N T

WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE VOTE VIA THE INTERNET OR OVER THE TELEPHONE AS INSTRUCTED IN THENOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALSAND ON THE ENCLOSED PROXY CARD OR, IF YOU REQUESTED AND RECEIVED A PRINTED COPY OF THE PROXY STATEMENT, COMPLETE, DATE, SIGN AND RETURN THE ENCLOSED PROXY CARD USING THE ENCLOSED RETURN ENVELOPE, AS PROMPTLY AS POSSIBLE IN ORDER TO ENSURE YOUR REPRESENTATION AT THE MEETING. EVEN IF YOU HAVE VOTED BY PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE MEETING. PLEASE NOTE, HOWEVER, THAT IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK OR OTHER NOMINEE AND YOU WISH TO VOTE AT THE MEETING, YOU MUST OBTAIN A PROXY CARD ISSUED IN YOUR NAME FROM THAT INTERMEDIARY.


LOGO

TABLE OF CONTENTS

PROXY STATEMENT FOR 2010 ANNUAL MEETING OF STOCKHOLDERS TO BE HELD ON FEBRUARY 18, 2010
GENERAL INFORMATION
PROPOSAL NO. 1 ELECTION OF DIRECTORS
THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE NOMINEES IDENTIFIED ABOVE.
PROPOSAL NO. 2 RATIFICATION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” PROPOSAL NO. 2.
CORPORATE GOVERNANCE
BOARD OF DIRECTORS AND COMMITTEES
EXECUTIVE OFFICERS
CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE
EQUITY COMPENSATION PLAN INFORMATION
EXECUTIVE COMPENSATION
DIRECTOR COMPENSATION
REPORT OF THE AUDIT COMMITTEE
OTHER BUSINESS
STOCKHOLDER PROPOSALS


(AVANIR LOGO)
10120 Enterprise, Suite 300
200

Aliso Viejo, California 92656

PROXY STATEMENT FOR
2010

2012 ANNUAL MEETING OF STOCKHOLDERS
To Be Held on February 18, 2010

TO BE HELD ON FEBRUARY 16, 2012

GENERAL INFORMATION

This Proxy Statement is furnished in connection with the solicitation of proxies by the Board of Directors (the“Board”Board) of Avanir Pharmaceuticals, Inc. ((““Avanir”Avanir or the“Company”Company) for use at the Company’s 20102012 annual meeting of stockholders, to be held at The Islandthe Renaissance Club Sport Aliso Viejo Hotel, 690 Newport Center Drive, Newport Beach,50 Enterprise, Aliso Viejo, California, on Thursday, February 18, 2010,16, 2012, at 9:00 a.m. local time. This proxy statement is being made available via the Internet on December 28, 200921, 2011 and the mailing date of the Notice Regarding the Availability of Proxy Materials (the“Notice”Notice) to our stockholders will be on or about January 8, 2010.

3, 2012.

The Notice instructs you as to how you may access and review important information contained in the proxy materials. The Notice also instructs you on how you may submit your proxy onvia the Internet. If you receive a Notice by mail and would like to receive a printed copy of our proxy materials, you should follow the instructions for requesting such materials included in the Notice.

For a proxy to be effective, it must be properly executed and received prior to the annual meeting. Each proxy properly tendered will, unless otherwise directed by the stockholder, be voted for the proposals and nominees described in this Proxy Statement and at the discretion of the proxy holder(s) with regard to all other matters that may properly come before the meeting.

The Company will pay all of the costs of soliciting proxies. We will provide copies of our proxy materials to brokerage firms, fiduciaries and custodians for forwarding to beneficial owners who request printed copies of these materials and will reimburse these persons for their costs of forwarding these materials. Our directors, officers and employees may also solicit proxies by telephone, facsimile, or personal solicitation; however, we will not pay them additional compensation for any of these services.

Shares Outstanding and Voting Rights

Only holders of record of our common stock ((“common stock”stock) at the close of business on December 22, 200919, 2011 (theRecord Date”Date), are entitled to notice of and to vote at the annual meeting. On the Record Date, 83,178,113132,467,537 shares of common stock were issued and outstanding. Each share of common stock is entitled to one vote on all matters to be voted upon at the annual meeting. Holders of common stock do not have the right to cumulative voting in the election of directors. The presence, in person or by proxy, of the holders of a majority of the outstanding shares on the Record Date will constitute a quorum for the transaction of business at the annual meeting and any adjournment thereof.

Persons who hold shares of Avanir common stock directly on the Record Date ((“record holders”holders) must return a proxy card or attend the annual meeting in person in order to vote on the proposals. Persons who hold shares of Avanir indirectly on the Record Date through a brokerage firm, bank or other financial institution ((“beneficial holders”holders) must return a voting instruction form to have their shares voted on their behalf. Brokerage firms, banks or other financial institutions that do not receive voting instructions from beneficial holders may either vote these shares on behalf of the beneficial holders or return a proxy leaving these shares un-voted (a “broker non-vote”non-vote).


Abstentions and broker non-votes will be counted for the purpose of determining the presence or absence of a quorum, but will not be counted for the purpose of determining the number of votes cast on a given proposal. The required vote for each of the proposals expected to be acted upon at the annual meeting is described below:

Proposal No. 1 — Election of directors. Directors are elected by a plurality, with the nominees obtaining the most votes being elected. Because there is no minimum vote required, abstentions and broker non-votes will be entirely excluded from the vote and will have no effect on its outcome. However, as described below, we have adopted a majority vote standard under our Bylaws, which means that directors may not be eligible to retain their Board seat if there is a greater number of votes against“AGAINST” their election than for.“FOR” their election. Under the majority vote standard, any shares that are not voted, whether by abstention, broker non-votes or otherwise, will not affect the election of directors, except to the extent that the failure to vote for an individual will result in another individual receiving a larger proportion of the votes cast.

Proposal No. 2 — Ratification of independent registered public accounting firm. This proposal must be approved by a majority of the shares castpresent and entitled to vote on thatthe proposal. As a result, abstentions will have the same effect as voting against the proposal and broker non-votes will have no effect on the vote outcome.

Proposal No. 3 — Advisory (non-binding) vote on executive compensation. This advisory proposal will be approved if a majority of the shares present and entitled to vote on the proposal are voted in favor of the resolution. As a result, abstentions will have the same effect as voting against the proposal and broker non-votes will have no effect on the vote outcome.

We encourage you to vote by proxy, whether via telephone, through the Internet or mailing an executed proxy card. By voting in advance of the meeting, this ensures that your shares will be voted and reduces the likelihood that the Company will be forced to incur additional expenses soliciting proxies for the annual meeting. Any record holder of our common stock may attend the annual meeting in person and may revoke the enclosed form of proxy at any time by:

executing and delivering to the corporate secretary a later-dated proxy;

delivering a written revocation to the corporate secretary before the meeting; or

• executing and delivering to the corporate secretary a later-dated proxy;
• delivering a written revocation to the corporate secretary before the meeting; or
• voting in person at the annual meeting.

voting in person at the annual meeting.

Beneficial holders of our common stock who wish to change or revoke their voting instructions should contact their brokerage firm, bank or other financial institution for information on how to do so. Beneficial holders who wish to attend the annual meeting and vote in person should contact their brokerage firm, bank or other financial institution holding shares of Avanir on their behalf in order to obtain a “legal proxy,” which will allow them to both attend the meeting and vote in person. Without a legal proxy, beneficial holders cannot vote at the annual meeting because their brokerage firm, bank or other financial institution may have already voted or returned a broker non-vote on their behalf.

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PROPOSAL NO. 1

ELECTION OF DIRECTORS

The Certificate of Incorporation of the Company provides that the Board is to be divided into three classes as nearly equal in number as reasonably possible, with directors in each class serving three-year terms. The total Board size is currently fixed at eightseven directors. Currently, the Class I directors (whose terms expire at the 2011 annual meeting of stockholders) are Stephen G. Austin, CPA and Dennis G. Podlesak. The Class II directors (whose terms expire at the 2012 annual meeting of stockholders) are Keith A. Katkin and Charles A. Mathews and Nicholas J. Simon.Mathews. The Class III directors (whose terms expire at the 20102013 annual meeting of stockholders) are David J. Mazzo, Ph.D., Craig A. Wheeler and Scott M. Whitcup, M.D. The Class IIII directors (whose terms expire at the 2014 annual meeting of stockholders) are Stephen G. Austin, CPA and Dennis G. Podlesak. Class II directors elected at the annual meeting will hold office until the 20132015 annual meeting of stockholders and until their successors are elected and qualified, unless they resign or their seats become vacant due to death, removal, or other cause in accordance with the Bylaws of the Company.

All three

As described below, the Board has nominated Messrs. Katkin and Mathews for reelection as Class II directors at the Annual Meeting. Both nominees have indicated their willingness to serve if elected. Should anyeither nominee become unavailable for election at the annual meeting, the persons named on the enclosed proxy as proxy holders may vote all proxies given in response to this solicitation for the election of a substitute nominee chosen by the Board.

Nomination of Directors

The Corporate Governance Committee, which acts as the Company’s nominating committee, reviews and recommends to the Board potential nominees for election to the Board. In reviewing potential nominees, the Corporate Governance Committee considers the qualifications of each potential nominee in light of the Board’s


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existing and desired mix of experience and expertise. Specifically, the Corporate Governance Committee considers each potential nominee’s scientific and business experience, skills and characteristics, wisdom, integrity, ability to make independent analytical inquiries, understanding of the Company’s business and prospects, and willingness to devote adequate time to Board duties. These criteria are set forth in our Corporate Governance Guidelines, a copy of which is available on our website atwww.avanir.com.

After reviewing the qualifications of potential Board candidates, the Corporate Governance Committee presents its recommendations to the Board, which selects the final director nominees. TheUpon the recommendation of the Corporate Governance Committee, recommended the nominees identified below.Board nominated Messrs. Katkin and Mathews for reelection as Class II directors. The Company did not pay any fees to any third parties to identify or assist in identifying or evaluating nominees for the annual meeting.

The Corporate Governance Committee considers stockholder nominees using the same criteria set forth above. Stockholders who wish to present a potential nominee to the Corporate Governance Committee for consideration for election at a future annual meeting of stockholders must provide the Corporate Governance Committee with notice of the nomination and certain information regarding the candidate within the time periods set forth below under the caption “Stockholder Proposals.”

Although the Corporate Governance Committee may consider whether nominees assist in achieving a mix of Board members that represents a diversity of background and experience, which is not only limited to race, gender or national origin, we have no formal policy regarding board diversity.

Nominees and Incumbent Directors

The NominatingCorporate Governance Committee has recommended, and the Board has nominated, Drs. MazzoMessrs. Katkin and Whitcup and Mr. WheelerMathews to be reelected Class IIIII directors at the annual meeting.

The following table sets forth the following information for these nominees and the Company’s continuing directors: the year each was first elected a director

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of the Company, their respective ages as of the date of filing of this proxy statement, the positions currently held with the Company, the year their current term will expire and their current class:

             
        Current
Nominee/Director Name
   Position(s) with the
 Year Current
 Director
and Year First Became a Director
 
Age
 
Company
 
Term Expires
 
Class
 
Nominees for Class III Directors:
            
David J. Mazzo, Ph.D. (2005)  53  Director  2010  III
Craig A. Wheeler (2005)  49  Chairman of the Board of Directors  2010  III
Scott M. Whitcup, M.D. (2005)  50  Director  2010  III
Continuing Directors:
            
Stephen G. Austin, CPA (2003)  57  Director  2011  I
Dennis G. Podlesak (2005)  52  Director  2011  I
Keith A. Katkin (2007)  38  President, Chief Executive Officer, Director  2012  II
Charles A. Mathews (2001)  71  Director  2012  II
Nicholas J. Simon (2008)  55  Director  2012  II

Nominee / Director Name

and Year First Became a Director

  Age   

Position(s) with the

Company

  Year Current
Term Expires
   Current
Director
Class
 
Nominees for Class II Directors:        

Keith A. Katkin (2007)

   40    President, Chief Executive Officer, Director   2012     II  

Charles A. Mathews (2001)

   73    Director   2012     II  
Continuing Directors:        

David J. Mazzo, Ph.D. (2005)

   54    Director   2013     III  

Craig A. Wheeler (2005)

   51    Chairman of the Board of Directors   2013     III  

Scott M. Whitcup, M.D. (2005)

   52    Director   2013     III  

Stephen G. Austin, CPA (2003)

   59    Director   2014     I  

Dennis G. Podlesak (2005)

   53    Director   2014     I  

Class IIIII Directors Nominated for Election

The following persons have been nominated by the Board to be elected as Class IIIII directors at the 20102012 annual meeting.

David J. Mazzo, Ph.D.Keith A. Katkinhas served as a Board member since February 2006. He is thewas appointed President and Chief Executive Officer of Regado Biosciences, Inc., a privately held,U.S.-based biopharmaceutical company developing novel aptamer-reversal agent pairs initially in the area of injectable antithrombotics. Prior to joining RegadoAvanir and until April 2008, Dr. Mazzo served as President and Chief Executive Officer of Æterna Zentaris, Inc., a global biopharmaceutical company with products and a therapeutic focus in the areas of oncology and endocrinology. Prior to joining Æterna Zentaris in March 2007, Dr. Mazzo had served as President and Chief Executive Officer of Chugai Pharma USA since April 2003. Dr. Mazzo has spent more than 20 years in the pharmaceutical industry and has held positions of increasing responsibility with Merck, Baxter, Rhône-Poulenc Rorer, Hoechst Marion Roussel and Schering-Plough. Dr. Mazzo holds a B.A. degree in Honors (Interdisciplinary Humanities) and a B.S. degree in Chemistry from Villanova University,


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as well as an M.S. degree in Chemistry and a Ph.D. degree in Analytical Chemistry from the University of Massachusetts (Amherst). He further complemented his American education as a Research Fellow at the Ecole Polytechnique Fédérale de Lausanne, Switzerland. Dr. Mazzo serveswas elected as a member of the boardBoard of directors of Regado Biosciences and as non-executive Chairman of the board of directors of pSivida, Inc. He is also a member of the board of trustees of Bonnie Brae Residential Treatment Center for Adolescent Boys (Liberty Corner, NJ).
Craig A. Wheelerhas served as our Chairman of the Board since May 2007. Mr. Wheeler serves as a director and as Chief Executive Officer of Momenta Pharmaceuticals, Inc. Prior to joining Momenta in August 2006, Mr. Wheeler was President of Chiron BioPharmaceuticals for five years, a division of Chiron Corporation, until it was acquired by Novartis AG in 2006. In this position he was responsible for all aspects of the division including commercial, research, development and manufacturing. He currently serves on the Cornell Biomedical Engineering Advisory Board. Mr. Wheeler holds B.S. and M.S. degrees in chemical engineering from Cornell University and an M.B.A. degree from the Wharton School of the University of Pennsylvania, where he majored in marketing and finance.
Scott M. Whitcup, M.D. joined the Board in February 2006. He serves as Executive Vice President and Head of Research and Development of Allergan, Inc. Dr. Whitcup has served in this role since July 2004 and is responsible for Allergan’s drug discovery efforts, as well as the ophthalmology, Botox®/neurology, urology, skin care, medical devices and other new technology development programs worldwide. Dr. Whitcup was given the additional title of Chief Scientific Officer in 2009. Dr. Whitcup joined Allergan in January 2000 as Vice President, Development, Ophthalmology and, in January 2004, he became Allergan’s Senior Vice President, Development, Ophthalmology. From 1993 until 2000, Dr. Whitcup served as the Clinical Director of the National Eye Institute at the National Institutes of Health. Dr. Whitcup is a faculty member at the Jules Stein Eye Institute / David Geffen School of Medicine at UCLA. Dr. Whitcup graduated from Cornell University Medical College and completed residency training both in internal medicine at UCLA Medical Center and in ophthalmology at the Massachusetts Eye and Ear Infirmary-Harvard Medical School. He then received fellowship training in uveitis and ocular immunology at the National Eye Institute.
Class I Directors continuing in office until 2011
Stephen G. Austin, CPAhas served as a Board member since March 2003. He has been a Partner in Swenson Advisors, LLP, a regional accounting firm (registered with the PCAOB), since May 1998 and has served as Managing Partner since October 2006. Prior to joining Swenson Advisors, Mr. Austin accumulated over 22 years of experience as an audit partner with Price Waterhouse LLP and with McGladrey & Pullen, LLP, serving both public and private companies. While at Price Waterhouse, Mr. Austin worked in their national office in New York, where he addressed complex accounting and reporting issues for publicly traded companies and worked with various members of the FASB and EITF staffs. Mr. Austin is licensed as a CPA in California and Georgia. He serves as a board member or advisory board member for variousnot-for-profit foundations, associations and public service organizations in the United States and serves on the Global board of directors of Integra International, an international federation of accounting firms. In 2004, Mr. Austin published a book on business ethics entitled, “Rise of the New Ethics Class,” and in 2005 and 2006 he published articles in Asia discussing The Sarbanes-Oxley Act of 2002.
Dennis G. Podlesakjoined the Board in March 2005.  He is a Partner at Domain Associates LLC, a life science focused venture capital firm, and has over 20 years of experience within the pharmaceutical industry. Prior to joining Domain in February 2008,2007. From July 2005 until March 2007, Mr. PodlesakKatkin served as the Chief Executive Officer and a member of the board of directors of Cerexa, Inc. since June 2005, which became a wholly owned subsidiary of Forest Laboratories after being acquired by Forest in January 2007. Cerexa was spun out of Peninsula Pharmaceuticals Inc., and while at Peninsula, Mr. Podlesak served as the Chief Executive Officer and as a member of the board of directors from September 2004 until he led the sale of Peninsula to Johnson & Johnson in June 2005. Prior to joining Peninsula, Mr. Podlesak served with Novartis AG as a Senior Vice President and Head of a North American Business Unit, and as a member of the Pharmaceutical Executive Committee and Global Leadership Team. Earlier in his career, Mr. Podlesak served as Vice President and Head of the CEC division of Allergan, Inc and was a member of Allergan’s North American and Global Management Team. Mr. Podlesak spent the first ten years of his career with SmithKline Beecham (now GlaxoSmithKline plc). Mr. Podlesak is also a member of the board of directors of Corthera, Inc., Regado Biosciences, DOV Pharmaceutical, Inc. and the non-profit organization Prevent Blindness. Mr. Podlesak received a B.A. degree in Business Administration and an M.B.A. degree from Pepperdine University.


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Class II Directors continuing in office until 2012
Keith Katkinjoined Avanir in July of 2005 as Senior Vice President of Sales and Marketing. In March 2007, Mr. Katkin was appointed President and Chief Executive Officer and was elected as a member of the Board. Prior to joining Avanir, Mr. Katkin previously served as Vice President, Commercial Development for Peninsula Pharmaceuticals, playing a key role in the management and ultimate sale of the company to Johnson & Johnson in 2005. Additionally, Mr. Katkin’s employment experience includes leadership roles at InterMune, Amgen and Abbott Laboratories. Mr. Katkin also served as strategic advisor to Cerexa, a pharmaceutical company that was sold to Forest Laboratories in 2007. Mr. Katkin received a B.S. degree in Business and Accounting from Indiana University and an M.B.A. degree in Finance from the Anderson School of Management at UCLA, graduating with honors. Mr. Katkin became a licensed Certified Public Accountant in 1995.
The Board has concluded that Mr. Katkin should serve on our Board based on his length of employment with the Company, deep knowledge of our Company gained from his positions as President and Chief Executive Officer and his substantial experience in the pharmaceutical industry.

Charles A. Mathewsserved as our Chairman of the Board from March 2005 through November 2006 and has served as a Board member since September 2001. Mr. Mathews also currently serves on our Audit Committee, Corporate Governance Committee and Executive Committee. Mr. Mathews is an active private investor and previously served as the president of the San Diego Tech Coast Angels, part of an affiliation of over 200 accredited “angel” investors active in the life science and technology industries. From April 2002 until January 2004, Mr. Mathews served as the President and Chief Executive Officer of DermTech International, a privately held contract research organization focused on dermal and transdermal drugs. From 1996 to April 2002, Mr. Mathews was an independent management consultant, providing CEO-level consulting services to various public and private companies. He currently serves as a director for Lpath Inc. and several privately held companies. During his career, Mr. Mathews has held general management responsibilities for companies operating in nine countries on three continents, and has served on boards of directors of over twenty companies in seven countries. Mr. Mathews is actively involved in community affairs including serving as the President and Treasurerelected director of Pauma Valley Community Services District.District and an appointed member of the Pala Pauma Sponsor Group. He was recognized as the 2003 Director of the Year for Corporate Governance by the Corporate Directors Forum, San Diego.

The Board believes that Mr. Mathews is a valuable addition to the Company’s Board of Directors due to Mr. Mathews’s extensive experience serving as a director and Chief Executive Officer of companies in the life science industry and his deep experience in serving as director of over twenty companies operating in seven different countries.

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Class III Directors continuing in office until 2013

NicholasDavid J. SimonMazzo, Ph.D.joined thehas served as a Board in May 2008.member since July 2005 and he currently serves on our Compensation Committee and Science Committee. He is the President and Chief Executive Officer of Regado Biosciences, Inc., a Managing Director of Clarus Ventures, LLC, a life sciences focused venture capital firm that he co-founded in 2005. He has been a General Partner of MPM BioVentures III since October 2001. In addition, Mr. Simon has over twenty years of operating experienceprivately held, U.S.-based biopharmaceutical company developing novel aptamer-reversal agent pairs initially in the area of injectable antithrombotics. Prior to joining Regado and until April 2008, Dr. Mazzo served as President and Chief Executive Officer of Æterna Zentaris, Inc., a global biopharmaceutical company with products and a therapeutic focus in the areas of oncology and endocrinology. Dr. Mazzo also served as a director of Æterna Zentaris from April 2007 through April 2008. Prior to joining Æterna Zentaris in March 2007, Dr. Mazzo had served as President and Chief Executive Officer of Chugai Pharma USA since April 2003. Dr. Mazzo has spent more than 28 years in the pharmaceutical industry including Genentechand has held positions of increasing responsibility with Merck, Baxter, Rhône-Poulenc Rorer, Hoechst Marion Roussel and Schering-Plough. Dr. Mazzo holds a B.A. degree in Honors (Interdisciplinary Humanities) and a B.S. degree in Chemistry from 1989 to 2000 where he was Vice PresidentVillanova University, as well as an M.S. degree in Chemistry and a Ph.D. degree in Analytical Chemistry from the University of Business and Corporate Development. Mr. Simon currentlyMassachusetts (Amherst). He further complemented his American education as a Research Fellow at the Ecole Polytechnique Fédérale de Lausanne, Switzerland. Dr. Mazzo serves onas a member of the board of directors of AchillionRegado Biosciences and as non-executive Chairman of the board of directors of pSivida, Inc. Based on Dr. Mazzo’s experience within the pharmaceutical industry and his executive experience, specifically his experience as Chief Executive Officer at other companies in the biotechnology industry, as well as his service on other boards of directors in the biotechnology industries, the Board believes Dr. Mazzo has the appropriate set of skills to serve as a member of our Board.

Craig A. Wheelerhas served as our Chairman of the Board since May 2007 and currently serves on our Audit Committee, Corporate Governance Committee and Executive Committee. Mr. Wheeler serves as a director and as Chief Executive Officer of Momenta Pharmaceuticals, Inc. (ACHN), ARYx Therapeutics (ARYX)Prior to joining Momenta in August 2006, Mr. Wheeler was President of Chiron BioPharmaceuticals for five years, a division of Chiron Corporation, until it was acquired by Novartis AG in 2006. In this position he was responsible for all aspects of the division including commercial, research, development and Poniard, Inc. (PARD), all publicly traded companies, and also Pearl Therapeutics, Inc., QuatRx Pharmaceuticals Company, Sientra, Inc., and Verus Pharmaceuticals, Inc., which are private biotech companies.manufacturing. Mr. Simon is alsoWheeler serves on the Board of Directors for the Generic Pharmaceutical Associates (GPHA) and is a member of their executive committee. He currently serves on the Cornell Biomedical Engineering Advisory Council atBoard, and serves on the Gladstone Institute, a privatenot-for-profit research institute affiliated withGene Partnership Advisory Board for the UniversityChildren’s Hospital of California, San Francisco.Boston. Mr. Simon received aWheeler holds B.S. degreeand M.S. degrees in microbiologychemical engineering from theCornell University of Maryland and an M.B.A. degree from Loyola College.

the Wharton School of the University of Pennsylvania, where he majored in marketing and finance. Mr. Wheeler’s experience within the pharmaceutical industry and his management experience at other companies in the biotechnology industry make him a valuable member of our Board.

Scott M. Whitcup, M.D. joined the Board in February 2006 and currently serves on our Corporate Governance Committee, Executive Committee and Science Committee. He serves as Executive Vice President and Head of Research and Development of Allergan, Inc. Dr. Whitcup has served in this role since July 2004 and is responsible for Allergan’s drug discovery efforts, as well as the ophthalmology, Botox®/neurology, urology, skin care, medical devices and other new technology development programs worldwide. Dr. Whitcup was given the additional title of Chief Scientific Officer in 2009. Dr. Whitcup joined Allergan in January 2000 as Vice President, Development, Ophthalmology and, in January 2004, he became Allergan’s Senior Vice President, Development, Ophthalmology. From 1993 until 2000, Dr. Whitcup served as the Clinical Director of the National Eye Institute at the National Institutes of Health. Dr. Whitcup is a faculty member at the Jules Stein Eye Institute / David Geffen School of Medicine at UCLA. Dr. Whitcup graduated from Cornell University Medical College and completed residency training both in internal medicine at UCLA Medical Center and in ophthalmology at the Massachusetts Eye and Ear Infirmary-Harvard Medical School. He then received fellowship training in uveitis and ocular immunology at the National Eye Institute. Dr. Whitcup’s scientific expertise and involvement in drug discovery efforts allow him to provide unique perspective to our operations and, accordingly, our Board believes Dr. Whitcup has the appropriate skill set to serve on our Board.

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Class I Directors continuing in office until 2014

Stephen G. Austin, CPAhas served as a Board member since March 2003 and currently serves on our Audit Committee and Compensation Committee. He has been a Partner in Swenson Advisors, LLP, a regional accounting firm (registered with the PCAOB), since May 1998 and has served as Managing Partner since October 2006. At Swenson Advisors, LLP, Mr. Austin manages audit, SEC, Sarbanes-Oxley and business consulting engagements with a focus on technology, manufacturing, service, real estate, social media and non-profit organizations. Prior to joining Swenson Advisors, Mr. Austin accumulated over 22 years of experience as an audit partner with Price Waterhouse LLP, where he worked from 1976 to 1996, and with McGladrey & Pullen, LLP, where he worked from 1996 to 1998, serving both public and private companies. While at Price Waterhouse, Mr. Austin worked in their national office in New York, where he addressed complex accounting and reporting issues for publicly-traded companies and worked with various members of the FASB and EITF staffs. Mr. Austin is licensed as a CPA in California and Georgia. He serves as a board member or advisory board member for various not-for-profit foundations, associations and public service organizations in the United States and serves on the Global board of directors of Integra International, an international association of accounting firms. In 2004, Mr. Austin published a book on business ethics entitled, “Rise of the New Ethics Class,” and in 2005 and 2006 he published articles in Asia discussing The Sarbanes-Oxley Act of 2002. In 2010 and 2011, Mr. Austin authored articles for the AICPA. Mr. Austin holds a B.S. degree in accounting from Bob Jones University and an M.B.A. degree from the University of Georgia. Based on Mr. Austin’s length of history with the Company, audit committee expertise and extensive experience serving as a director of other companies, the Board believes Mr. Austin has the appropriate set of skills to serve as a member of our Board.

Dennis G. Podlesakjoined the Board in March 2005 and currently serves on our Compensation Committee and Science Committee. He is a Partner at Domain Associates LLC, a life science focused venture capital firm, and has over 20 years of experience within the pharmaceutical industry. Prior to joining Domain in November 2007, Mr. Podlesak served as the Chief Executive Officer and a member of the board of directors of Cerexa, Inc. since June 2005, which became a wholly owned subsidiary of Forest Laboratories after being acquired by Forest in January 2007. Cerexa was spun out of Peninsula Pharmaceuticals Inc., and, while at Peninsula, Mr. Podlesak served as the Chief Executive Officer and as a member of the board of directors from September 2004 until he led the sale of Peninsula to Johnson & Johnson in June 2005. Prior to joining Peninsula, Mr. Podlesak served with Novartis AG as a Senior Vice President and Head of a North American Business Unit, and as a member of the Pharmaceutical Executive Committee and Global Leadership Team. Earlier in his career, Mr. Podlesak served as Vice President and Head of the CEC division of Allergan, Inc. and was a member of Allergan’s North American and Global Management Team. Mr. Podlesak spent the first ten years of his career with SmithKline Beecham (now GlaxoSmithKline plc). Mr. Podlesak has served on a number of public company and private boards, and is currently a member of the board of directors of Adynxx, Inc., Regado Biosciences, Syndax Pharmaceuticals and the non-profit organization Prevent Blindness. Most recently, Mr. Podlesak was Chairman of Corthera, Inc., which was acquired by Novartis AG in January 2010 and was also the Founder, Chief Executive Officer, and board member of Calixa Therapeutics, which was acquired by Cubist in December 2009. Mr. Podlesak received a B.A. degree in Business Administration from Western Illinois University and an M.B.A. degree from Pepperdine University and has completed postgraduate studies at the Wharton School, University of Pennsylvania. Based on Mr. Podlesak’s experience within the pharmaceutical industry and his executive experience, specifically his experience as Chief Executive Officer at other companies in the biotechnology industry, as well as his service on other boards of directors in the biotechnology industries, the Board believes Mr. Podlesak has the appropriate set of skills to serve as a member of our Board.

Vote Required

The nominees who receive the greatest number of affirmative votes of the shares present in person or by proxy will be elected as Class IIIII directors. Any shares that are not voted, whether by abstention, broker non-votes or otherwise, will not affect the election of directors, except to the extent that the failure to vote for an individual will result in another individual receiving a larger proportion of the votes cast. If anyeither nominee receives more votes against his election than for his election and that nominee is nevertheless elected under the plurality vote

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standard, that director will be required under our Bylaws to submit a conditional resignation to the Company. This resignation will then be considered by the Corporate Governance Committee, taking into account the circumstances of the election, and a recommendation will be presented to the disinterested members of the Board, who will then vote whether to accept the resignation.

Holders of proxies solicited by this Proxy Statement will vote the proxies received by them as directed on the proxy card or, if no direction is made, then FOR the election of all theboth nominees named in this Proxy Statement.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR”

THE NOMINEES IDENTIFIED ABOVE.


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7


PROPOSAL NO. 2

RATIFICATION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Our Audit Committee has selected KMJ Corbin & Company, LLP ((““KMJ”KMJ) as our independent registered public accounting firm for the fiscal year ending September 30, 2010,2012, and has further directed that we submit the selection of KMJ for ratification by our stockholders at the annual meeting.

The Company is not required to submit the selection of our independent registered public accounting firm for stockholder approval. However, if the stockholders do not ratify this selection, the Audit Committee will reconsider its selection of KMJ. Even if the selection is ratified, our Audit Committee may direct the appointment of a different independent registered public accounting firm at any time during the year if the Audit Committee determines that the change would be in the best interests of the Company.

The Audit Committee reviews and pre-approves all audit and non-audit services performed by its independent registered public accounting firm, as well as the fees charged for such services. All fees incurred in fiscal 20092011 for services rendered by KMJ were approved in accordance with these policies. In its review of non-audit service fees, the Audit Committee considers, among other things, the possible impact of the performance of such services on the auditor’s independence. The Audit Committee has determined that the non-audit services performed by KMJ in the fiscal year ended September 30, 20092011 were compatible with maintaining the auditor’s independence. Additional information concerning the Audit Committee and its activities can be found in the following sections of this Proxy Statement: “Board Committees” and “Report of the Audit Committee.”

KMJ has reviewed our interim financial statements since the quarter ended March 31, 2007 and commenced auditinghas audited our annual financial statements forsince the fiscal year ended September 30, 2007. Representatives of KMJ are expected to be present at the annual meeting, will have the opportunity to make a statement if they desire to do so and will be available to respond to appropriate stockholder questions.

Fees for Independent Registered Public Accounting Firm

The following is a summary of the fees billed to the Company by KMJ for professional services rendered for the fiscal years ended September 30, 20092011 and 2008.2010. These fees are for work invoiced in the fiscal years indicated.

         
  2009  2008 
 
Audit Fees:
        
Consists of fees billed for professional services rendered for the audit of the Company’s annual financial statements and the review of the interim financial statements included in the Company’s Quarterly Reports (together, the“Financial Statements”) and for services normally provided in connection with statutory and regulatory filings or engagements
 $198,050  $296,435 
Other Fees:
        
Audit-Related Fees
        
Consists of fees billed for assurance and related services reasonably related to the performance of the annual audit or review of the Financial Statements (defined above)  11,400   28,691 
Tax Fees
        
Consists of fees billed for tax compliance, tax advice and tax planning  1,400   1,600 
All Other Fees
        
Consists of fees billed for other products and services not described above(1)  34,620   35,764 
         
Total Other Fees  47,420   66,055 
         
Total All Fees
 $245,470  $362,490 
         
(1)Consists of fees relating to: (i) the review of registration statements filed under the Securities Act of 1933 and the issuance of consents, (ii) routine audits of an employee benefit plan and research program supported by federal grants, and (iii) equity compensation consulting.

   2011   2010 

Audit Fees:

    

Consists of fees billed for professional services rendered for the audit of the Company’s annual financial statements and the review of the interim financial statements included in the Company’s Quarterly Reports (together, the “Financial Statements”) and for services normally provided in connection with statutory and regulatory filings or engagements

  $232,832    $174,427  

Other Fees:

    

Audit-Related Fees

    

Consists of fees billed for assurance and related services reasonably related to the performance of the annual audit or review of the Financial Statements (defined above)

   52,205     31,412  

Tax Fees

    

Consists of fees billed for tax compliance, tax advice and tax planning

   —       —    

All Other Fees

    

Consists of fees billed for other products and services not described above, which consisted of fees relating to: accounting policy and auditor consent

   23,055     11,335  
  

 

 

   

 

 

 

Total Other Fees

   75,260     42,747  
  

 

 

   

 

 

 

Total All Fees

  $308,092    $217,174  
  

 

 

   

 

 

 

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Vote Required

Ratification of the selection of the independent registered public accounting firm requires the affirmative vote of a majority of the shares present in person or by proxy and votingentitled to vote on the proposal. Abstentions will have the same effect as voting against the proposal. Because abstentions and broker non-votes are not counted as votes for or against this proposal, they will have no effect on the outcome of the vote.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” PROPOSAL NO. 2.


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9


PROPOSAL NO. 3

ADVISORY VOTE ON EXECUTIVE COMPENSATION

Background

The Dodd-Frank Wall Street Reform and Consumer Protection Act (the “Dodd-Frank Act”) requires that stockholders have the opportunity to cast an advisory (non-binding) vote on executive compensation (a so-called “say-on-pay” vote), as well as an advisory vote with respect to whether future say-on-pay votes will be held every one, two or three years (a so-called “say-on-frequency” vote).

We conducted both a say-on-pay vote and say-on-frequency vote at our 2011 Annual Meeting of Stockholders. At such meeting, a majority of stockholders present and entitled to vote on the proposals (i) approved the say-on-pay proposal and (ii) selected one year as the desired frequency of future stockholder say-on-pay votes with respect to the say-on-frequency proposal. In light of the results of such stockholder vote, the Board adopted a resolution to hold a say-on-pay vote annually. Accordingly, this Proposal No. 3 seeks an advisory vote of stockholders with respect to the executive compensation of the Company’s named executive officers.

The advisory vote on executive compensation is a non-binding vote on the compensation of the Company’s “named executive officers,” as described in the Compensation Discussion and Analysis section, the tabular disclosure regarding such compensation, and the accompanying narrative disclosure, set forth in this proxy statement. The advisory vote on executive compensation is not a vote on the Company’s general compensation policies, compensation of the Company’s Board of Directors, or the Company’s compensation policies as they relate to risk management.

Our philosophy in setting compensation policies for executive officers has two fundamental objectives: (1) to attract, motivate and retain a highly skilled team of executives and (2) to align our executives’ interests with those of our stockholders by rewarding short-term and long-term performance and tying compensation to increases in stockholder value. The Compensation Committee believes that executive compensation should be directly linked both to continuous improvements in corporate performance (so-called “pay for performance”) and accomplishments that are expected to increase stockholder value. The Compensation Discussion and Analysis section starting on page 18 provides a more detailed discussion of the executive compensation program and compensation philosophy.

The vote under this Proposal No. 3 is advisory, and therefore not binding on the Company, the Board or our Compensation Committee. However, our Board, including our Compensation Committee, values the opinions of our stockholders and, to the extent there is any significant vote against the executive officer compensation as disclosed in this proxy statement, we will consider our stockholders’ concerns and evaluate what actions may be appropriate to address those concerns.

Stockholders will be asked at the Annual Meeting to approve the following resolution pursuant to this Proposal No. 3:

RESOLVED, that the stockholders of Avanir Pharmaceuticals, Inc. approve, on an advisory basis, the compensation of the Company’s “named executive officers” (as defined in the Proxy Statement), as such compensation is described in the Compensation Discussion and Analysis section, the tabular disclosure regarding such compensation, and the accompanying narrative disclosure, set forth in the Company’s definitive proxy statement for the 2012 Annual Meeting of Stockholders.

Recommendation

The Board of Directors recommends a vote “FOR” approval of the foregoing resolution. Proxies will be so voted unless stockholders specify otherwise in their proxies.

Vote Required

Approval of this resolution requires the affirmative vote of a majority of the shares present in person or by proxy and entitled to vote on the matter. Abstentions will have the same effect as voting against the resolution. Because broker non-votes are not counted as votes for or against this resolution, they will have no effect on the outcome of the vote.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” PROPOSAL NO. 3.

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CORPORATE GOVERNANCE

Director Independence

We believe that the Company benefits from having a strong and independent Board. For a director to be considered independent, the Board must determine that the director does not have any direct or indirect material relationship with the Company that would affect his or her exercise of independent judgment. On an annual basis, the Board reviews the independence of all directors under guidelines established by NASDAQ and in light of each director’s affiliations with the Company and members of management, as well as significant holdings of Company securities. This review considers all known relevant facts and circumstances in making an independence determination. Based on this review, the Board has made an affirmative determination that all directors, other than Mr. Katkin, are independent. It was determined that Mr. Katkin lacks independence because of his status as the Company’s President and Chief Executive Officer.

Code of Business Conduct and Ethics

We believe that our Board and committees, led by a group of strong and independent directors, provide the necessary leadership, wisdom and experience that the Company needs in making sound business decisions. Our Code of Business Conduct and Ethics helps clarify the operating standards and ethics that we expect of all of our officers, directors and employees in making and implementing those decisions. Waivers of our Code of Business Conduct and Ethics may only be granted by the Board or the Corporate Governance Committee and will be publicly announced promptly in our SEC filings. In furthering our commitment to these principles, we invite you to review our Code of Business Conduct and Ethics and other corporate governance materials located on our website atwww.avanir.com.

Stockholder Communications

Generally, stockholders who have questions or concerns regarding the Company should contact our Investor Relations department at(949) 389-6700. However, any stockholders who wish to address questions regarding the business or affairs of the Company directly with the Board, or any individual director, should direct his or her questions in writing to the Chairman of the Board, Avanir Pharmaceuticals, Inc., 10120 Enterprise, Suite 300,200, Aliso Viejo, California 92656. Upon receipt of any such communications, the correspondence will be directed to the appropriate person, including individual directors.

BOARD OF DIRECTORS AND COMMITTEES

During fiscal 2009,2011, our Board met sixeight times. Each director attended at least 75% of the aggregate of the meetings of the Board and meetings of the committees of which he was a member in our last fiscal year. During fiscal 2009,2011, our Board had an Audit Committee, a Compensation Committee, a Corporate Governance Committee, an Executive Committee and a Science Committee. All members of the Audit, Compensation, Corporate Governance and Science Committees are non-employee directors who are deemed independent.

All members of our Board attended the 20092011 Annual Meeting of Stockholders. Although the Company has no formal policies regarding director attendance at annual meetings, it does expect that all members of the Board will attend the 20102012 Annual Meeting.

Board Leadership Structure and Risk Oversight

The positions of Chairman of the Board and Chief Executive Officer are separated, which allows our Chief Executive Officer to focus on our day-to-day business, while allowing the Chairman of the Board to lead the Board in its fundamental role of providing advice to and independent oversight of management. Our Board recognizes the time, effort, and energy that the Chief Executive Officer is required to devote to his position in the current business environment, as well as the commitment required to serve as our Chairman. Our Board also believes that this structure ensures a greater role for the independent directors in the oversight of our Company and active participation of the independent directors in setting agendas and establishing priorities and procedures for the work of our Board. Our Board believes its administration of its risk oversight function has not affected its leadership structure.

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While our Bylaws do not require that our Chairman and Chief Executive Officer positions be separate, our Board believes that having separate positions and having an independent outside director serve as Chairman is the appropriate leadership structure for us at this time and demonstrates our commitment to good corporate governance. Our separated Chairman and Chief Executive Officer positions are augmented by the independence of six of our seven directors, and our independent Board committees that provide appropriate oversight in the areas described below. At executive sessions of independent directors, these directors speak candidly on any matter of interest, which may be with or without the Chief Executive Officer present. The Board of Directors met in executive session four times in 2011. We believe this structure provides consistent and effective oversight of our management and the Company.

The Board has overall responsibility for the oversight of the Company’s risk management process, which is designed to support the achievement of organizational objectives, including strategic objectives, to improve long-term organizational performance and enhance stockholder value. Risk management includes not only understanding company-specific risks and the steps management implements to manage those risks, but also what level of risk is acceptable and appropriate for the Company. Management is responsible for establishing our business strategy, identifying and assessing the related risks and implementing appropriate risk management practices. The Board periodically reviews our business strategy and management’s assessment of the related risk, and discusses with management the appropriate level of risk for the Company, especially in light of the fact that the Company again has a marketed product and may face additional risk management concerns that it did not face while developing product candidates, such as risk of off-label promotion and other risks associated with marketed products. The Board also delegates oversight to Board committees to oversee selected elements of risk as set forth below.

Board Committees

Audit Committee. As of the Record Date, the Audit Committee was comprised of Messrs. Austin (Chairman), Mathews and Wheeler. The Audit Committee selects the Company’s independent registered public accounting firm, approves its compensation, oversees and evaluates the performance of the independent registered public accounting firm, oversees the accounting and financial reporting policies and internal control systems of the Company, reviews the Company’s interim and annual financial statements, independent registered public accounting firm reports and management letters, and performs other duties, as specified in the Audit Committee Charter, a copy of which is available on the Company’s website atwww.avanir.com. Additionally, the Audit Committee is involved in the oversight of the Company’s risk management through its practice of having a head of the Company’s different business functions report on risk management issues within his or her respective business division at each quarterly meeting of the Audit Committee. The Audit Committee met nineseven times in fiscal 2009.2011. All members of the Audit Committee satisfy the current independence standards promulgated by NASDAQ and the SEC and the Board has determined that Mr. Austin is an “audit committee financial expert,” as the SEC has defined that term in Item 407 ofRegulation S-K.

Compensation Committee. As of the Record Date, the Compensation Committee was comprised of Dr. Mazzo (Chairman) and Messrs. Podlesak and Austin. The Compensation Committee determines compensation levels for the Company’s executive officers and directors, oversees administration of the Company’s equity


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compensation plans, and performs other duties regarding compensation for employees and consultants as the Board may delegate from time to time. Our Chief Executive Officer makes recommendations to the Compensation Committee regarding the corporate and individual performance goals and objectives relevant to executive compensation and executives’ performance in light of such goals and objectives, and recommends other executives’ compensation levels to the Compensation Committee based on such evaluations. The Compensation Committee considers these recommendations and then makes an independent decision regarding officer compensation levels and awards. The Compensation Committee met sixfive times in fiscal 2009.2011. A copy of the Compensation Committee charter is available on the Company’s website atwww.avanir.com. All members of the Compensation Committee satisfy the current NASDAQ independence standards.

Corporate Governance Committee. As of the Record Date, the Corporate Governance Committee was comprised of Messrs. Mathews (Chairman) and Wheeler and Dr. Whitcup. The Corporate Governance

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Committee oversees the Company’s Code of Conduct, develops and implements policies and processes regarding corporate governance matters, assesses Board membership needs and acts as the Company’s nominating committee by reviewing potential director nominees and recommending nominees to the Board. The Corporate Governance Committee met fivesix times in fiscal 2009.2011. A copy of the Corporate Governance Committee charter is available on our website atwww.avanir.com. All members of the Corporate Governance Committee satisfy the current NASDAQ independence standards.

Executive Committee. As of the Record Date, the Executive Committee was comprised of Messrs. Wheeler (Chairman), Katkin and Mathews and Dr. Whitcup. Subject to certain exceptions, the Executive Committee is authorized to act on any matter that the Board may consider when the Board is not in session. The Executive Committee met twicedid not meet in fiscal 2009.

2011.

Science Committee. As of the Record Date, the Science Committee was comprised of Drs. Whitcup (Chairman) and Mazzo and Messrs. Podlesak and Simon.Mr. Podlesak. The Science Committee advises management and the Board on scientific and regulatory matters relating to the Company’s drugs and drug candidates.candidates, including reviewing medical affairs policies and practices of the Company and reviewing key scientific, clinical and medial aspects of significant proposed business development activities. The Science Committee reviews both pre-clinical studies and clinical trials of Avanir’s research programs, and provides advice on the design, conduct, and analyses of these data. The Science Committee is also responsible for reviewing and providing advice on scientific issues relating to drug manufacturing and intellectual property related to Avanir’s scientific research. The Science Committee met sixfive times in fiscal 2009.

2011.

Compensation Committee Interlocks and Insider Participation

During the last completed fiscal year, no member of the Compensation Committee was a current or former officer or employee of Avanir. None of our executive officers served as a member of the compensation committee (or board of directors serving the compensation function) of another entity where such entity’s executive officers served on our Compensation Committee. Moreover, none of our executive officers served as a member of the compensation committee (or board of directors serving the compensation function) of another entity where such entity’s executive officers served on our Board.


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EXECUTIVE OFFICERS AND KEY EMPLOYEES

Our current executive officers and key employees and their respective ages and positions as of December 21, 2011 are set forth in the following table. Biographical information regarding each executive officer and key employee who is not also a director is set forth following the table.

Biographical information for Mr. Katkin is set forth above under Proposal No. 1 (Election of Directors).

Name

Age   

Position

Keith A. Katkin

   
Name
Age
Position
Keith A. Katkin3840    President and Chief Executive Officer
Randall E. Kaye, M.D. 

Gregory J. Flesher

   4741Senior Vice President and Chief Business Officer

Randall E. Kaye, M.D.

49    Senior Vice President and Chief Medical Officer
Christine G. Ocampo

Joao Siffert, M.D.

   3748Senior Vice President, Research and Development

Christine G. Ocampo

39    Vice President, Finance (principal financial officer)

Gregory J. Flesher. Mr. Flesher joined Avanir in June 2006 as Senior Director of Commercial Strategy, assumed the additional responsibility for Business Development and Portfolio Planning in November 2006 and was promoted to Vice President of Business Development in August 2007. In February of 2011, he was promoted to Senior Vice President and Chief Business Officer. Prior to joining Avanir, Mr. Flesher held positions as Director of Sales – Hepatology (from 2004 to 2006) and Director of Marketing — Pulmonary at InterMune, Inc. (from 2002 to 2004). Prior to his tenure at InterMune, Mr. Flesher held both oncology and nephrology marketing positions with Amgen Inc., a global biotechnology company, from 1999 to 2002. Mr. Flesher also has global marketing and clinical development experience from Eli Lilly and Company, where he worked from 1995 to 1998. Mr. Flesher graduated from Purdue University with a Bachelor of Science in Biology and has completed his doctorate coursework in Biochemistry and Molecular Biology at Indiana University School of Medicine.

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Randall E. Kaye, M.D. Dr. Kaye was appointed Senior Vice President and Chief Medical Officer in March 2007. From November 2006 until March 2007, he served as Vice President Clinical and Medical Affairs, and from January 2006 to November 2006 as Vice President of Medical Affairs. Immediately prior to joining Avanir, Dr. Kaye was the Vice President of Medical Affairs for Scios Inc., a division of Johnson & Johnson, from 2004 to 2006. From 2002 to 2004, Dr. Kaye recruited and managed the Medical Affairs department for InterMune Inc. Previously, Dr. Kaye served for nearly a decade in a variety of Medical Affairs and Marketing positions for Pfizer Inc. Dr. Kaye earned his Doctor of Medicine, Masters in Public Health and Bachelor of Science degrees at George Washington University in Washington, D.C. and was a Research Fellow in Allergy and Immunology at Harvard Medical School.

Joao Siffert, M.D. Dr. Siffert joined Avanir in August 2011 as Senior Vice President, Research and Development. Dr. Siffert previously served as Vice President and Chief Medical Officer at Ceregene, Inc., a biotechnology company focused on the development of neurotrophic gene therapies for Alzheimer’s and Parkinson’s diseases, from September 2007 to August 2011. Prior to his work at Ceregene, Dr. Siffert served as the Chief Medical Officer at Avera Pharmaceuticals, a CNS specialty pharmaceutical company, from May 2005 to September 2007. Prior to joining Avera, Dr. Siffert held positions with Pfizer (from February 2002 to May 2005) first as a medical director for Relpax and subsequently as the worldwide medical team leader of Lyrica and Neurontin focusing in areas of pain and epilepsy. Prior to Pfizer, Dr. Siffert held academic positions at Beth Israel Medical Center, where he served as director of the Adult Neuro-Oncology program, and Albert Einstein College of Medicine, where he was assistant professor of neurology. Dr. Siffert completed residencies in pediatrics at New York University School of Medicine and in neurology at Harvard Medical School. Dr. Siffert was certified by the American Board of Neurology and Psychiatry in 1996. He holds an M.D. degree from the University of Sao Paulo School of Medicine as well as an M.B.A. degree from Columbia University Business School.

Christine G. Ocampo. Ms. Ocampo was appointed Vice President, Finance in February 2008. Ms. Ocampo previously served as the Company’s Controller since March 2007. Prior to joining the Company, Ms. Ocampo served as Senior Vice President, Chief Financial Officer, Chief Accounting Officer, Treasurer and Secretary of Cardiogenesis Corporation from November 2003 until April 2006. From 2001 to November 2003, Ms. Ocampo served in the role of Vice President and Corporate Controller at Cardiogenesis. Prior to joining Cardiogenesis in April 1997, Ms. Ocampo held a management position in Finance at Mills-Peninsula Health Systems in Burlingame, California, and spent three years as an auditor for Ernst & Young LLP. Ms. Ocampo graduated with a BachelorsBachelor of Science in Accounting from Seattle University and became a licensed Certified Public Accountant in 1996.

CERTAIN RELATIONSHIPS AND RELATED PARTYRELATED-PARTY TRANSACTIONS

Transactions with Related Parties

Other than compensation arrangements described below under the captions “Executive Compensation” and “Director Compensation,” we are not a party to any transactions between us and certain “related parties,” which are generally considered to be our directors and executive officers, nominees for director, holders of 5% or more of our outstanding common stock and members of their immediate families.

Related-Party Transaction Review and Approval

Our Board has adopted policies and procedures for the review and approval of related partyrelated-party transactions and has delegated to the Corporate Governance Committee the authority to review and approve the material terms of any proposed related partyrelated-party transactions. To the extent that a proposed related partyrelated-party transaction may involve a non-employee director or nominee for election as a director and may be material to a consideration of that person’s independence, the matter may also be considered by the other disinterested directors.

Pursuant to our Code of Business Conduct and Ethics and our Corporate Governance Committee Charter, each of our executive officers and directors must disclose related partyrelated-party transactions to our Corporate Governance Committee. In order to avoid conflicts of interest, our executive officers and directors may not acquire any

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ownership interest in any supplier, customer or competitor (other than nominal amounts of stock in publicly traded companies), enter into any consulting or employment relationship with any customer, supplier or competitor, or engage in any outside business activity that is competitive with any of our businesses, without first disclosing the proposed transaction. After the proposed transaction has been disclosed, a determination will be made by our Corporate Governance Committee as to what course to follow, depending on the nature or extent of the conflict. Furthermore, our executive officers and directors may not serve on any board of directors of any customer, supplier or competitor unless such board service has been disclosed to us and approved by our Board. Our Corporate Governance Committee has been delegated the task of reviewing other directorships and consulting agreements of Board members for conflicts of interest. All members of our Board are required to report annually all other directorships and consulting agreements.


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In determining whether to approve or ratify a related-party transaction, the Corporate Governance Committee may consider, among other factors it deems appropriate, the potential benefits to us, the impact on a director’s or nominee’s independence or an executive officer’s relationship with or service to us, whether the related partyrelated-party transaction is on terms no less favorable than terms generally available to an unaffiliated third party under the same or similar circumstances and the extent of the related party’s interest in the transaction. In deciding to approve a transaction, the Corporate Governance Committee may, in its sole discretion, impose such conditions as it deems appropriate on us or the related party in connection with its approval of any transaction. Any transactions involving the compensation of executive officers, however, are to be reviewed and approved by the Compensation Committee. If a related-party transaction will be ongoing, the Corporate Governance Committee may establish guidelines to be followed in our ongoing dealings with the related party. Thereafter, the Corporate Governance Committee, on at least an annual basis, will review and assess ongoing relationships with the related party to see that they are in compliance with the committee’s guidelines and that the related-party transaction remains appropriate.
SECURITY OWNERSHIP OF CERTAIN
BENEFICIAL OWNERS AND MANAGEMENT
Based on information available to us and filings with the SEC the following table sets forth certain information regarding the beneficial ownership (as defined byRule 13d-3 under the Securities Exchange Act of 1934) of our outstanding common stock for (i) each of our directors, (ii) each of our “named executive officers,” as defined in Executive Compensation below, (iii) all of our directors and executive officers as a group, and (iv) persons known to us to beneficially hold more than 5% of our outstanding common stock. The following information is presented as of September 30, 2009 or such other date as may be reflected below.
Beneficial ownership and percentage ownership are determined in accordance with the rules of the SEC and include voting or investment power with respect to shares of stock. This information does not necessarily indicate beneficial ownership for any other purpose. Under these rules, shares of common stock issuable under stock options or warrants that are exercisable within 60 days of September 30, 2009 are deemed outstanding for the purpose of computing the percentage ownership of the person holding the options or warrant(s), but are not deemed outstanding for the purpose of computing the percentage ownership of any other person.
Unless otherwise indicated and subject to applicable community property laws, to our knowledge, each stockholder named in the following table possesses sole voting and investment power over their shares of common stock, except for those jointly owned with that person’s spouse. Unless otherwise indicated below, the address of each person listed on the table isc/o Avanir Pharmaceuticals, Inc., 101 Enterprise, Suite 300, Aliso Viejo, California 92656.


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  Shares Beneficially Owned 
     Percent of
 
Name of Beneficial Owner
 Number(1)  Class(2) 
 
Greater than 5% Holders
        
Clarus Ventures, LLC(3)  16,874,379   19.99%
One Memorial Drive
Cambridge, MA 02142
        
ProQuest Investments(4)  11,613,595   13.54%
90 Nassau Street, 5th Floor
Princeton, NJ 08542
        
Vivo Ventures(5)  8,329,662   9.99%
575 High Street, Suite 201
Palo Alto, CA 94301
        
Current directors and named executive officers:
        
Nicholas J. Simon(3)  16,874,379   19.99%
Keith A. Katkin(6)  611,640   * 
Randall E. Kaye, M.D.(7)  424,089   * 
Craig A. Wheeler(8)  233,844   * 
Charles A. Mathews(9)  186,969   * 
Stephen G. Austin, CPA(10)  180,094   * 
Dennis G. Podlesak(11)  174,844   * 
David J. Mazzo, Ph.D.(12)  174,844   * 
Scott M. Whitcup, M.D.(13)  173,844   * 
Christine G. Ocampo(14)  76,900   * 
All current executive officers and directors as a group (10 persons)  19,111,447   22.60%
Represents beneficial ownership of less than 1%.
(1)Represents shares of common stock and shares of restricted stock held as of September 30, 2009, plus shares of common stock that may be acquired upon exercise of options, warrants and other rights exercisable within 60 days of September 30, 2009. Certain purchasers of warrants from our April 2008 offering have elected to block the exercise of these warrants, subject to a61-day notice period for the removal of this “blocker” provision. This blocker has the effect of excluding the warrant shares from the beneficial ownership calculations set forth above.
(2)Based on 83,084,182 shares of common stock outstanding as of September 30, 2009. The percentage ownership and voting power for each person (or all directors and executive officers as a group) is calculated by assuming the exercise or conversion of all options, warrants and convertible securities exercisable or convertible within 60 days of September 30, 2009 held by such person and the non-exercise and non-conversion of all outstanding warrants, options and convertible securities held by all other persons.
(3)Based on Schedule 13D/A filed June 19, 2008 by Clarus Lifesciences I, L.P. (“Clarus I”), Clarus Ventures I GP, L.P. (“Clarus I GPLP”), Clarus Ventures I, LLC (“Clarus I GPLLC”), Nicholas Galakatos (“Galakatos”), Dennis Henner (“Henner”), Robert Liptak (“Liptak”), Nicholas Simon (“Simon”), Michael Steinmetz (“Steinmetz”), and Kurt Wheeler (“Wheeler”). Clarus I GPLP is the sole general partner of Clarus I. Clarus I GPLLC is the sole general partner of Clarus I GPLP. Galakatos, Henner, Liptak, Simon, Steinmetz, and Wheeler are all of the managing directors of Clarus I GPLLC. On April 4, 2008, Clarus I purchased 15,557,318 shares of common stock, as well as warrants exercisable for up to 5,445,061 shares of common stock (the “Warrant”). The exercise of the Warrant is limited so that Clarus I may only exercise that portion of the Warrant such that Clarus I’s beneficial ownership does not exceed 19.99% on a post-exercise basis. Accordingly, Clarus I has the right to acquire beneficial ownership, within 60 days of September 30, 2009, of only 1,317,061 additional shares of common stock underlying the Warrant. Each of these reporting persons disclaims beneficial ownership of all shares of common stock other than those shares that such person

11


owns of record. Simon currently serves on the Company’s Board and has agreed to forego any director compensation, including the receipt of equity awards granted to other non-employee directors.
(4)Based on Schedule 13G/A filed September 8, 2009 on behalf of the following persons: (i) ProQuest Investments III, L.P., a Delaware limited partnership (“Investments III”), with respect to shares beneficially owned by it; (ii) ProQuest Associates III LLC, a Delaware limited liability company (“Associates III”), as General Partner of Investments III with respect to Shares beneficially owned by Investments III; (iii) ProQuest Investments IV, L.P., a Delaware limited partnership (“Investments IV”), with respect to Shares beneficially owned by it; (iv) ProQuest Associates IV LLC, a Delaware limited liability company (“Associates IV”), as General Partner of Investments IV with respect to Shares beneficially owned by Investments IV; (v) Jay Moorin, an individual and a member of Associates III and Associates IV (“Moorin”), with respect to Shares beneficially owned by Associates III and Associates IV; and (vi) Alain Schreiber, an individual and a member of Associates III and Associates IV (“Schreiber”), with respect to Shares beneficially owned by Associates III and Associates IV. Reported holdings consist of 8,904,746 shares of common stock and 2,708,849 shares of common stock issuable upon the exercise of warrants. The warrants contain a limitation on exercise, which, in combination with an agreement between the reporting persons and the Company, prevents the reporting persons from exercising any warrants if, after giving effect to the exercise the reporting persons would, in the aggregate, beneficially own more than 19.99% of the outstanding shares of common stock.
(5)Based on Schedule 13G filed August 18, 2009 on behalf of Vivo Ventures Fund VI, L.P., a Delaware limited partnership (“Vivo Fund”), with respect to shares beneficially held by it, and Vivo Ventures VI, LLC, a Delaware limited liability company (“Vivo Ventures VI”), as general partner of Vivo Fund and Vivo Ventures VI Affiliates Fund L.P. (“Affiliates Fund”), with respect to shares beneficially held by Vivo Fund and Affiliates Fund. Includes 8,049,553 shares of common stock and 3,060,109 of common stock underlying warrants that are exercisable within 60 days of September 30, 2009. The warrants contain a limitation on exercise, which, in combination with an agreement between the reporting persons and the Company, prevents the reporting persons from exercising any warrants if, after giving effect to the exercise the reporting persons would, in the aggregate, beneficially own more than 9.99% of the outstanding shares of common stock. Accordingly, Vivo Ventures has the right to acquire beneficial ownership, within 60 days of September 30, 2009, of only 280,109 additional shares of common stock underlying the warrants. Each of the reporting persons disclaims beneficial ownership of such securities except to the extent of the reporting person’s pecuniary interest in such securities.
(6)Includes (i) 67,813 shares of common stock issuable upon the exercise of options exercisable within 60 days of September 30, 2009, (ii) 526,327 shares underlying restricted stock units granted under the Company’s equity plans and (iii) 17,500 shares of common stock.
(7)Includes (i) 25,782 shares of common stock issuable upon the exercise of options exercisable within 60 days of September 30, 2009 and (ii) 398,307 shares underlying restricted stock units granted under the Company’s equity plans, including 12,500 shares of common stock that are held by certain family members and for which Dr. Kaye disclaims beneficial ownership.
(8)Includes (i) 6,250 shares of common stock issuable upon the exercise of options exercisable within 60 days of September 30, 2009 and (ii) 227,594 shares underlying restricted stock units granted under the Company’s equity plans.
(9)Includes (i) 15,000 shares of common stock issuable upon the exercise of options exercisable within 60 days of September 30, 2009, (ii) 167,594 shares underlying restricted stock units granted under the Company’s equity plans, (iii) 1,875 shares of common stock held in Mr. Mathews’s individual retirement account, for which Mr. Mathews is the beneficial owner, and (iv) 2,500 shares of common stock.
(10)Includes (i) 10,000 shares of common stock issuable upon the exercise of options exercisable within 60 days of September 30, 2009, (ii) 167,594 shares underlying restricted stock units granted under the Company’s equity plans and (iii) 2,500 shares of common stock.
(11)Includes (i) 6,250 shares of common stock issuable upon the exercise of options exercisable within 60 days of September 30, 2009, (ii) 167,594 shares underlying restricted stock units granted under the Company’s equity plans that will vest and be issued within 60 days from October 1, 2009 and (iii) 1,000 shares of common stock.


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(12)Includes (i) 6,250 shares of common stock issuable upon the exercise of options exercisable within 60 days of September 30, 2009, (ii) 167,594 shares underlying restricted stock units granted under the Company’s equity plans and (iii) 1,000 shares of common stock.
(13)Includes (i) 6,250 shares of common stock issuable upon the exercise of options exercisable within 60 days of September 30, 2009 and (ii) 167,594 shares underlying restricted stock units granted under the Company’s equity plans.
(14)Includes (i) 7,500 shares of common stock issuable upon the exercise of options exercisable within 60 days of September 30, 2009, (ii) 69,400 shares underlying restricted stock units granted under the Company’s equity plans and (iii) 11,900 shares of common stock held by certain family members and for which Ms. Ocampo is a beneficial owner.
SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

Section 16(a) of the Exchange Act requires our executive officers and directors, and persons who own more than 10% of a registered class of our equity securities, to file reports of beneficial ownership and changes in beneficial ownership with the SEC. Executive officers, directors and greater-than-10% stockholders are required by SEC regulations to furnish us with copies of all reports filed under Section 16(a). To the Company’s knowledge, based solely on the review of copies of the reports furnished tofiled with the Company,SEC, all reports required to be filed by our executive officers, directors and greater-than-10% stockholders were timely filed in fiscal 2009, except that a greater-than-10% holder failed to timely file a Form 3 reporting their purchase of shares from us in April 2008 and a Form 4 reporting the disposition of a portion of their holdings; both filings were made in August 2009.

2011.

EQUITY COMPENSATION PLAN INFORMATION

The following table sets forth certain information, as of September 30, 2009,2011, regarding the Company’s Amended and Restated 1994, 1998 and 2000 Stock Option Plans and 2003 and 2005 Equity Incentive Plans, as well as other stock options and warrants previously issued by the Company as compensation for services.

                 
        Number of Securities
    
  Number of Securities
     Remaining Available for
    
  to be Issued Upon
     Future Issuance Under
    
  Exercise of
  Weighted-Average
  Equity Compensation
    
  Outstanding Options,
  Exercise Price of
  Plans (Excluding
    
  Warrants and
  Outstanding Options,
  Securities Reflected in
    
Plan category
 Rights(1)  Warrants and Rights  First Column)(2)    
 
Equity compensation plans approved by security holders  366,940  $8.24   988,869     
Equity compensation plans not approved by security holders  3,850,216  $0.91   4,110,271     
                 
Total  4,217,156  $1.55   5,099,140     
                 
                 

Plan category

  Number of Securities
to  be Issued Upon
Exercise of
Outstanding Options,
Warrants and
Rights(1)
   Weighted-Average
Exercise Price of
Outstanding Options,
Warrants and Rights
   Number of  Securities
Remaining Available for
Future Issuance Under
Equity Compensation

Plans (Excluding
Securities Reflected in
First Column) (2)
 

Equity compensation plans approved by security holders

   338,309    $8.29     574,382  

Equity compensation plans not approved by security holders

   7,745,587    $2.20     7,557,780  

Total

   8,083,896    $2.46     8,132,162  

(1)Excludes a total of 2,505,4341,798,144 shares of common stock issuable upon the vesting of outstanding restricted stock units.

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(2)Excludes shares that may be added pursuant to the “evergreen” features under the Amended and Restated 2003 and 2005 Equity Incentive Plans. 325,000 additional shares were authorized for issuance in November 20092011 under the “evergreen” feature contained in the 2005 Equity Incentive Plan.

SECURITY OWNERSHIP OF CERTAIN

BENEFICIAL OWNERS AND MANAGEMENT

Based on information available to us and filings with the SEC, the following table sets forth certain information regarding the beneficial ownership (as defined by Rule 13d-3 under the Securities Exchange Act of 1934) of our outstanding common stock for (i) each of our directors, (ii) each of our “named executive officers,” as defined in Executive Compensation below, (iii) all of our directors and executive officers as a group, and (iv) persons known to us to beneficially hold more than 5% of our outstanding common stock. The following information is presented as of December 1, 2011 or such other date as may be reflected below.

Beneficial ownership and percentage ownership are determined in accordance with the rules of the SEC and include voting or investment power with respect to shares of stock. This information does not necessarily indicate beneficial ownership for any other purpose. Under these rules, shares of common stock issuable under stock options or warrants that are exercisable within 60 days of December 1, 2011 are deemed outstanding for the purpose of computing the percentage ownership of the person holding the options or warrant(s), but are not deemed outstanding for the purpose of computing the percentage ownership of any other person.

Unless otherwise indicated and subject to applicable community property laws, to our knowledge, each stockholder named in the following table possesses sole voting and investment power over their shares of common stock, except for those jointly owned with that person’s spouse. Unless otherwise indicated below, the address of each person listed on the table is c/o Avanir Pharmaceuticals, Inc., 20 Enterprise, Suite 200, Aliso Viejo, California 92656.

   Shares Beneficially Owned 

Name and Address of Beneficial Owner

  Number(1)   Percent of
Class(2)
 

Greater than 5% Holders

    

T. Rowe Price Associates, Inc. (3)

   18,712,447     14.7

100 E. Pratt Street

    

Baltimore, MD 21202

    

Ingalls & Snyder LLC (4)

   13,136,340     10.3

61 Broadway

    

New York, NY 10006

    

FMR LLC (5)

   7,418,410     5.8

82 Devonshire

    

Boston, MA 02109

    

BlackRock Institutional Trust Company, N.A. (6)

   6,770,447     5.3

400 Howard Street

    

San Francisco, CA 94105

    

Vanguard Group, Inc. (7)

   6,535,262     5.1

P.O. Box 2600

    

Valley Forge, PA 19482-2600

    

Current directors and named executive officers:

    

Keith A. Katkin (8)

   1,223,561     1.0

Craig A. Wheeler (9)

   308,844     *  

Charles A. Mathews (10)

   250,719     *  

Stephen G. Austin, CPA (11)

   250,094     *  

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   Shares Beneficially Owned 

Name and Address of Beneficial Owner

  Number(1)   Percent of
Class(2)
 

Dennis G. Podlesak (12)

   244,844     *  

David J. Mazzo, Ph.D. (13)

   244,844     *  
Scott M. Whitcup, M.D. (14)   243,844     *  

William J. Sibold

   —       *  

Joao Siffert, M.D.

   —       *  

Christine G. Ocampo (15)

   208,121     *  

All current executive officers and directors as a group (9 persons)

   2,974,871     2.3

*Less than one percent.

(1)Represents shares of common stock and shares of restricted stock held as of December 1, 2011, plus shares of common stock that may be acquired upon exercise of options, warrants and other rights exercisable within 60 days of December 1, 2011.

(2)Based on 126,959,119 shares of the registrant’s Common Stock that were issued and outstanding as of December 1, 2011. The percentage ownership and voting power for each person (or all directors and executive officers as a group) is calculated by assuming the exercise or conversion of all options, warrants and convertible securities exercisable or convertible within 60 days of December 1, 2011 held by such person and the non-exercise and non-conversion of all outstanding warrants, options and convertible securities held by all other persons.

(3)Based on a Schedule 13F-HR filed November 14, 2011 on behalf of T. Rowe Price Associates, Inc.

(4)Based on a Schedule 13F-HR filed October 25, 2011 on behalf of Ingalls & Snyder LLC.

(5)Based on a Schedule 13F-HR filed November 14, 2011 on behalf of FMR LLC.

(6)Based on a Schedule 13F-HR filed November 3, 2011 on behalf of BlackRock Institutional Trust Company, N.A. and a Schedule 13F-HR filed November 3, 2011 on behalf of BlackRock Fund Advisors.

(7)Based on a Schedule 13F-HR filed November 15, 2011 on behalf of Vanguard Group, Inc.

(8)Includes (i) 1,032,704 shares of common stock issuable upon the exercise of options exercisable within 60 days of December 1, 2011, (ii) 31,250 shares underlying restricted stock units granted under the Company’s equity plans and (iii) 159,607 shares of common stock.

(9)Includes (i) 6,250 shares of common stock issuable upon the exercise of options exercisable within 60 days of December 1, 2011 and (ii) 302,594 shares underlying restricted stock units granted under the Company’s equity plans.

(10)Includes (i) 8,750 shares of common stock issuable upon the exercise of options exercisable within 60 days of December 1, 2011, (ii) 237,594 shares underlying restricted stock units granted under the Company’s equity plans, (iii) 1,875 shares of common stock held in Mr. Mathews’s individual retirement account, for which Mr. Mathews is the beneficial owner, and (iv) 2,500 shares of common stock held directly by Mr. Mathews. Mr. Mathews has shared voting and shared investment power with respect to 246,344 shares of common stock that are subject to the terms of the Mathews Family Trust U/A, dated 7/21/1992, of which Stephanie Mathews is a co-trustee with power of independent action.

(11)Includes (i) 10,000 shares of common stock issuable upon the exercise of options exercisable within 60 days of December 1, 2011, (ii) 237,594 shares underlying restricted stock units granted under the Company’s equity plans and (iii) 2,500 shares of common stock.

(12)Includes (i) 6,250 shares of common stock issuable upon the exercise of options exercisable within 60 days of December 1, 2011, (ii) 237,594 shares underlying restricted stock units granted under the Company’s equity plans and (iii) 1,000 shares of common stock.

(13)Includes (i) 6,250 shares of common stock issuable upon the exercise of options exercisable within 60 days of December 1, 2011, (ii) 237,594 shares underlying restricted stock units granted under the Company’s equity plans and (iii) 1,000 shares of common stock.

(14)Includes (i) 6,250 shares of common stock issuable upon the exercise of options exercisable within 60 days of December 1, 2011 and (ii) 237,594 shares underlying restricted stock units granted under the Company’s equity plans.

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(15)Includes (i) 157,975 shares of common stock issuable upon the exercise of options exercisable within 60 days of December 1, 2011, (ii) 5,625 shares underlying restricted stock units granted under the Company’s equity plans, (iii) 32,621 shares of common stock and (iv) 11,900 shares of common stock held by certain family members and for which Ms. Ocampo is the beneficial owner.

EXECUTIVE COMPENSATION

Compensation Discussion and Analysis

The following compensation discussion and analysis describes the material elements of compensation earned in fiscal 20092011 by each of the current and former executive officers identified below in the Summary Compensation Table, who are referred to collectively as our “named executive officers.” Our named executive officers with respect to the fiscal year that ended on September 30, 20092011 are Keith A. Katkin, President and Chief Executive Officer; Joao Siffert, M.D., Senior Vice President, Research and Development; and Christine G. Ocampo, Vice President, Finance; and Randall E. Kaye, M.D.,Finance, as well as William J. Sibold, our former Senior Vice President and Chief MedicalCommercial Officer. These persons constitute our “principalprincipal executive officer” (as defined under SEC rules)officer, principal financial officer and two other executive officers serving during fiscal 2009.2011. This disclosure includes payments that were made and compensation-related


13


actions that were taken in the first quarter of fiscal 2010,2012, where these payments and decisions related to performance in fiscal 2009.
2011.

Compensation Philosophy and Objectives

Our philosophy in setting compensation policies for our named executive officers has two fundamental objectives: (1) to attract, motivate and retain a highly skilled team of executives and (2) to align our executives’ interests with those of our stockholders by rewarding short-term and long-term performance and tying compensation to increases in stockholder value. The Compensation Committee believes that executive compensation should be both directly linked both to continuous improvements in corporate performance (so-called “pay(“pay for performance”) and accomplishments that are expected to increase stockholder value. In furtherance of this goal, the Compensation Committee has adhered to the following guidelines as a foundation for decisions that affect the levels of compensation:

provide a competitive total compensation package that enables the Company to attract and retain highly qualified executives with the skills and experience required for the achievement of business goals;

align compensation elements with the Company’s annual goals and long-term business strategies and objectives;

• provide a competitive total compensation package that enables the Company to attract and retain highly qualified executives with the skills and experience required for the achievement of business goals;
• align compensation elements with the Company’s annual goals and long-term business strategies and objectives;
• promote the achievement of key strategic and financial performance measures by linking short-term and long-term cash and equity incentives to the achievement of measurable corporate and individual performance goals; and
• align executives’ incentives with the creation of stockholder value.

promote the achievement of key strategic and financial performance measures by linking short-term and long-term cash and equity incentives to the achievement of measurable corporate and individual performance goals; and

align executives’ incentives with the creation of stockholder value.

The Compensation Committee has historically compensated the Company’s named executive officers with three compensation components: base salary, annual incentive bonus and equity-based compensation. The Compensation Committee believes that cash compensation in the form of base salary and an annual incentive bonus provides our executives with short-term rewards for success in operations, and that long-term compensation through the award of stock options, restricted stock and other equity awards aligns the objectives of management with those of our stockholders with respect to long-term performance and success.

As a pharmaceutical company engaged in the development of products for potential commercialization, the Company currently does not generate significant revenues or profits. As a result, the

The Compensation Committee places additional emphasisalso has historically focused on the Company’s financial and working capital condition when making compensation decisions and approving performance objectives. Accordingly,Because the Compensation CommitteeCompany has had limited sources of capital and historically has sought to preserve cash, overall compensation traditionally has been weighted more heavily toward contingent performance-based payments, such as annual incentive bonuses, and equity-based compensation more heavily in order to tie a substantial portionthat is earned only upon the Company’s achievement of specified performance goals. Although the Company commercially launched its product, NUEDEXTA™, during the second quarter of the executives’ total compensation to2011 fiscal year, the Company’s performance. TheCompany currently does not generate significant revenues or profits. Accordingly, the Compensation Committee will continue to periodically reassess the appropriate weighting of equitycash and cashequity compensation in light of the Company’s expenditures in connection with its product launch and its working capital situation.

needs with the goal of more equally weighting cash compensation and long-term equity compensation in the future.

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Risk Management and Mitigation

In reviewing the compensation structure in fiscal 2009,2011, the Compensation Committee also considered how the Company’s compensation policies may affect the Company’s risk profile and how compensation policies may be used to mitigate risks facing the Company. More specifically, the Compensation Committee considered the general design philosophy of the Company’s policies for employees whose conduct would be most affected by incentives established by compensation policies. In considering these issues, the Compensation Committee concluded that the use of performance-based bonuses and long-term equity awards did not appear to create undue risks for the Company or encourage excessive risk-taking behavior on the part of employees.

With respect to bonus awards, the sizeamount of an individual’s award depends principally (exclusively, in the case of our Chief Executive Officer) on overall companyCompany performance, which reduces the ability and incentive for an individual to take undue risks in an effort to increase the amount of his or her performance rewards at the end ofbonus award for a particular year. The Company’s performance goals are reviewed and approved by the Compensation Committee at the beginning of each fiscal year and are considered to be generally of the nature that would not encourage or reward excessive risk taking. Additionally, the Compensation Committee monitors Company performance throughout the year and ishas the ability to intervene in a position to influenceinstances where actions by the Company vis-à-vis Company performance goal attainment that would be considered unduly risky.

risky to prevent or penalize such actions.

With respect to equity awards, these awards typically vest over several years, meaning that long-term value creation, contrasted with short-term gain, presents the best opportunity for employees to profit from these awards. To the extent that performance-based equity awards are used, the events that trigger vesting are expected to be realized several years in the future, such as the restricted awards previously granted with vesting tied to the Food and Drug Administration’s


14


(“FDA”) acceptance of the Company’s new drug application (“NDA”) for Zenvia for PBA.future. The Company has not historically used claw-back provisions or imposed holding periods for vested awards, although the Compensation Committee will consider whether such mechanisms might be appropriate in the future to mitigate risk as the Company transitions from a drug development company to a fully integrated specialty pharmaceutical company with commercial operations.
Additionally, the use of financial-based performance metrics to determine employee compensation may subject those payouts to claw-back penalties under the Dodd-Frank Act, to the extent that there is a subsequent restatement of the financial measure that was used to determine a payout.

Roles in Determining Compensation

Compensation Committee

The Board has delegated to the Compensation Committee the responsibility to ensure that total compensation paid to our executive officers, including named executive officers, is consistent with our compensation policy and objectives. The Compensation Committee oversees and approves all compensation arrangements and actions for our executive officers and other key employees, including the named executive officers. While the Compensation Committee draws on a number of resources, including input from the Chief Executive Officer and independent compensation consultants, to make decisions regarding the Company’s executive compensation program, ultimate decision-making authority rests with the Compensation Committee. The Compensation Committee retains discretion over base salary, annual incentive bonus, equity compensation and other compensation considerations. The Compensation Committee relies upon the judgment of its members in making compensation decisions, after reviewing the performance of the Company and carefully evaluating an executive’s performance during the year against established goals, operational performance and business responsibilities. In addition, the Compensation Committee incorporates judgment in the assessment process to respond to and adjust for the evolving business environment. Corporate goals are reviewed annually by the Compensation Committee and then presented to the full Board for review and approval.

Compensation Consultant

The Compensation Committee retains the services of an external compensation consultant, Radford, Surveys + Consulting, a division of AONAn AonHewitt Company (“Radford”). The mandate of the consultant is to assist the Compensation Committee in its review of executive and director compensation practices, including the competitiveness of pay levels, executive

19


compensation design, benchmarking with the Company’s peers in the industry and other technical considerations including tax- and accounting-related matters. The Compensation Committee regularly evaluates Radford’s performance, considers alternative compensation consultants and has the final authority to engage and terminate Radford’s services.

The Compensation Committee, after a review of the factors set forth in Section 10C(b) of the Securities Exchange Act of 1934, has determined that Radford is an independent compensation consultant.

Chief Executive Officer

The Chief Executive Officer attends Compensation Committee meetings and works with the Compensation Committee Chairman and Radford to develop compensation recommendations for the executive officers (excluding the Chief Executive Officer), based upon individual experience and breadth of knowledge, internal considerations, individual performance during the fiscal year and other factors deemed relevant by the Compensation Committee. The recommendations are then submitted to the Compensation Committee for review and consideration. The Compensation Committee works directly with Radford and the Chairman of the Board to determine compensation actions for the Chief Executive Officer.

Competitive Market Benchmarking

The Compensation Committee draws on a number of resources to assist in the evaluation of the various components of the Company’s executive compensation program including, but not limited to, industry data compiled yearly by Radford in its Global Life Sciences Survey, which represents a nationally-based assessment of executive compensation widely used within the pharmaceutical and biotechnology industry sectors. While we do not establish compensation levels based solely on benchmarking, pay practices at other companies are an important factor that the Compensation Committee considers in assessing the reasonableness of compensation and ensuring that our compensation practices are competitive in the marketplace. Accordingly,The peer companies adopted by the Company following the FDA approval of NUEDEXTA in October 2010 and used in determining compensation actions in the 2011 fiscal year were selected by the Compensation Committee with Radford’s support in fiscal 20082010 on the basis of the Company’s anticipation of the approval decision for NUEDEXTA, their similarity to us in terms of competition for talent, phase of development or stage of commercialization, current and potential market capitalization, and number of employees. The list of peer companies used in determining compensation actions in the 2011 fiscal year consisted of the following 26 publicly-traded companies in the pharmaceutical and biotechnology industries:

Acorda Therapeutics

DyaxPain Therapeutics

Affymax

Isis PharmaceuticalsPozen

Alexza Pharmaceuticals

MAP PharmaceuticalsSavient Pharmaceuticals

Alkermes

Momenta PharmaceuticalsSeattle Genetics

Allos Therapeutics

Nektar TherapeuticsSomaxon Pharmaceuticals

AMAG Pharmaceuticals

NPS PharmaceuticalsTheravance

Arena Pharmaceuticals

Optimer PharmaceuticalsVical

Cadence Pharmaceuticals

Orexigen TherapeuticsViroPharma

Cypress Pharmaceuticals

Osiris Therapeutics

The Compensation Committee reviews the Company’s list of peer companies periodically to reflect changes in market capitalization, developments at the Company relative to its peer companies and other factors. During fiscal 2011, the Compensation Committee noted that the above list of peer companies, selected in fiscal 2010, was in need of updating to reflect changes in market capitalization, developments at the peer companies, and other factors. Accordingly, the Compensation Committee engaged Radford to assist in determining a new list of peer companies following the Compensation Committee’s criteria, including phase of development and stage of

20


commercialization, current and potential market capitalization, and number of employees. The peer group selected was comprised of the following companies:

Acorda Therapeutics

Isis PharmaceuticalsPozen

Affymax

ISTA PharmaceuticalsQuestcor Pharmaceuticals

Alkermes

MAP PharmaceuticalsSavient Pharmaceuticals

Allos Therapeutics

Momenta PharmaceuticalsSeattle Genetics

AMAG Pharmaceuticals

Nektar TherapeuticsSomaxon Pharmaceuticals

Cadence Pharmaceuticals

NPS PharmaceuticalsTheravance

Cell Therapeutics

Optimer PharmaceuticalsVical

Dyax

Osiris TherapeuticsViroPharma

Halozyme Therapeutics

Pain TherapeuticsVIVUS

In May 2011, the Compensation Committee adopted the new list of peer companies that were determined to be more comparable to the Company’s business following the commercial launch of NUEDEXTA during the second quarter of the 2011 fiscal year. The Compensation Committee considered various factors, including number of employees, market capitalization and stage of commercialization, to select the comparator companies. In addition to the selection of the new list of peer companies, the Compensation Committee engaged Radford to conduct a comprehensive benchmarking study to reportreporting on compensation levels and practices, including equity, relative to the Company’s new list of peer companies in the pharmaceutical and biotechnology industries. Peer group selection was determined by specific criteria obtained from public filings and Radford’s 2008 Global Life Sciences Survey, including a peer company’s stage of development, number of employees and market capitalization.companies. An Executive Compensation ReviewAssessment report was prepared by Radford in July 2008August 2011 that provided a competitive assessment of the Company’s executive compensation program as compared to the market data for base salaries, target total cash compensation and equity compensation.


15


Based on Radford’s assessmentcompensation of the new list of peer companies. In consideration of the benchmarking data for the new peer companies and recommendation,the Company’s performance in fiscal 2008 the Compensation Committee selected 18 publicly-traded companies2011, adjustments to compensation were made in the pharmaceutical and biotechnology industries, which were determined to be generally similar in termsfirst quarter of competition for talent, phase of products in development, financial attributes, research and development expenditures, and stock price. The peer group selected in fiscal 2008 was comprised of the following companies:
ARYX TherapeuticsIntrogen TherapeuticsSomaxon Pharmaceuticals
AvigenLa Jolla PharmaceuticalsTelik
Cypress BioscienceNPS PharmaceuticalsTitan Pharmaceuticals
CytRxOptimer PharmaceuticalsTrubion Pharmaceuticals
Discovery LaboratoriesOrexigen TherapeuticsVanda Pharmaceuticals
FavrillePeregrine PharmaceuticalsVical
In August 2009, the Compensation Committee determined that it would not commission a new benchmarking study for fiscal 2009. In lieu of a newly-prepared study, the market data compiled and the Executive Compensation Review report prepared by Radford in fiscal 2008 was updated using a 3.0% average market increase for 2009 and recommendations provided by Radford. This served2012, as the benchmark for the guidelines used by the Compensation Committee’s executive compensation decisions in fiscal 2009.
described below.

Implementation of Objectives

In fiscal 2009,2011, our executive compensation program consisted of the following forms of compensation, each of which are described below in greater detail:

• Base Salary
• Annual Bonus Incentive
• Equity Compensation
• Employee Benefit Program

Base Salary

Annual Bonus Incentive

Equity Compensation

Employee Benefit Program

Base Salary

Overview

Our Compensation Committee aims to set executives’ base salaries, in the aggregate, at levels near the 50th50th percentile of salaries of executives with similar roles as compared to the Company’s peer group. The Compensation Committee believes it is important to provide adequate fixed compensation to our executive officers working in a highly volatile and competitive industry. Our Compensation Committee believes that the 50th50th percentile for base salaries is the minimum cash compensation level that will allow us to attract and retain highly skilled executives. The Compensation Committee’s choice of this target percentile reflects consideration

of our stockholders’ interests in paying what is necessary to achieve our corporate goals, while conserving cash

21


and equity as much as practicable. We believe that, given the industry in which we operate and our compensation philosophy and objectives, base salaries at the 50th50th percentile are generally sufficient to retain our current executives and to hire new executives when and as required. In determining appropriate base salary levels for a given executive officer, the Compensation Committee considers the following factors:

individual performance of the executive, as well as our overall performance, during the prior year;

level of responsibility, including breadth, scope and complexity of the position;

• individual performance of the executive, as well as our overall performance, during the prior year;
• level of responsibility, including breadth, scope and complexity of the position;
• level of experience and expertise of the executive;
• internal review of the executive’s compensation relative to other executives to ensure internal equity; and
• executive officer compensation levels at other similar companies to ensure competitiveness.

level of experience and expertise of the executive;

internal review of the executive’s compensation relative to other executives to ensure internal equity; and

executive officer compensation levels at other similar companies to ensure competitiveness.

Salaries for executive officers are determined on an individual basis at the time of hire and are set to be competitive with peer companies in our industry. Adjustments to base salary are considered annually in light of each executive officer’s individual performance, the Company’s performance and compensation levels at peer companies in our industry, as well as changes in job responsibilities or promotion. The Chief Executive Officer assists the Compensation Committee in its annual review of the base salaries of other executive officers based on the foregoing criteria.


16


Changes in Base Salaries for Fiscal 20102012
Radford’s

The Executive Compensation Assessment report prepared by Radford in August 2011 provided a competitive assessment in fiscal 2008 of the Company’s compensation practices as compared to that of the Company’s new list of peer companies and suggested that on average,the 2011 base salary levels for the majority of the Company’s named executive officersexecutives were at or belowbetween the 25th percentile25th and 50th percentiles as compared to the Company’s peer group. In light of the Company’s financial and working capital condition,growth following the FDA’s approval of NUEDEXTA in fiscal 2011, the Compensation Committee recommended to continue with the plan, previously approved ain fiscal 2011, of staged increaseincreases to the Company’s executives over a two to three yearthree-year period starting in fiscal 20082011. The plan is intended to provide base salary adjustments to the Company’s named executive officersexecutives whose base salaries are below market levels for the 50th50th percentile, with the goal of bringing base salaries to competitive base salary levels at or near the 50th percentile.50th percentile by the end of the three-year period. Any increase would be capped at 9.9% annually (unless the base salary for any executive is below market levels for the 25th percentile, in which case the Compensation Committee would, at its discretion, approve an increase above such cap to bring the officer to the 25th percentile) and would take into consideration the executives’ tenure in their respective roles, performance, job criticality, and merit increases for each of the fiscal 2008 and fiscal 2009, targeted at 4.2% and 3.0%, respectively, as suggested by Radford.years during the three-year period. The Compensation Committee deemed the base salary adjustmentsthis strategy to be reasonableconsistent with the Company’s stated compensation philosophy and objectives considering the experience levels of the executives and necessary in order to retain key executives needed to achieve the Company’s goals and business objectives. Following the end of fiscal 2009,2011, the Compensation Committee approved thea second adjustment to base salariessalaries. This second adjustment, which represents a market-based adjustment of compensation, will take effect subject to the achievement of a certain revenue level during the 2012 fiscal year and is in conjunction withaddition to the merit-based increase that is typically awarded during the first quarter of each fiscal year.

In fixing the target for the revenue goal, the Compensation Committee deemed it appropriate to establish a performance goal that was believed to be aggressive, meaning that it would be considered achievable, but only with a high degree of diligence and success in execution.

The following table shows the base salaries for our named executive officers for fiscal 2010,2012 (excluding Mr. Sibold, who is no longer employed with the Company), after giving effect to salary adjustmentsmerit-based increases made in

22


November 2009,2011, which were effective as of October 1, 2009,2011, as well as the average salaries in our new peer group at the 25th, 50th25th, 50th and 75th75th percentiles.

                   
       Base Salary — Market Data(2) 
    Fiscal 2010
  25th
  50th
  75th
 
Name
 
Title
 Base Salary(1)  Percentile  Percentile  Percentile 
 
Keith A. Katkin President and Chief
Executive Officer
 $410, 199  $414,884  $444,754  $494,194 
Randall E. Kaye, MD Senior Vice President and
Chief Medical Officer
 $336,467  $293,859  $314,459  $348,140 
Christine G. Ocampo Vice President, Finance $210,678  $206,000  $220,625  $242,256 

       

Potential

Fiscal 2012

  

Base Salary — Market Data(3)

 
    Fiscal 2012   25th  50th  75th 

Name

 

Title

 Base Salary(1)  Base Salary(2)  Percentile  Percentile  Percentile 

Keith A. Katkin

 President and Chief
Executive Officer
 $505,716   $530,506   $504,800   $560,400   $652,700  

Joao Siffert, M.D.

 Senior Vice President,

Research and Development

 $351,604   $351,604   $319,700   $349,200   $372,400  

Christine G.
Ocampo

 Vice President, Finance $224,562   $236,670   $239,200   $258,000   $274,600  

(1)Effective as of October 1, 2009.2011.

(2)Potential base salaries after giving effect to second (market-based) adjustment, which will only apply subject to the achievement of certain revenue levels.

(3)Source: Radford’s Executive Compensation Review of July 2008, subject to a 3% increase for fiscal 2009.August 2011.
The table below shows fiscal 2009

Fiscal 2011 and 20102012 base salary levels for each named executive officer:

               
    Fiscal 2009
  Fiscal 2010
  Percentage
 
Name
 
Title
 Base Salary  Base Salary(1)  (%) Increase 
 
Keith A. Katkin President and Chief
Executive Officer
 $373,248  $410,199   9.9%
Randall E. Kaye, MD Senior Vice President and
Chief Medical Officer
 $326,667  $336,467   3.0%
Christine G. Ocampo Vice President, Finance $197,820  $210,678   6.5%
officer

    Fiscal 2011  Fiscal 2012  Fiscal 2012 

Name

 

Title

 Base Salary  Base Salary(1)  Base Salary(2) 

Keith A. Katkin

 President and Chief
Executive Officer
 $495,800   $505,716   $530,506  

Joao Siffert, M.D.

 Senior Vice President,
Research and Development
 $350,000   $351,604   $351,604  

Christine G. Ocampo

 Vice President, Finance $220,159   $224,562   $236,670  

(1)Effective as of October 1, 2009.2011, inclusive of merit-based increase.

(2)Potential base salaries after giving effect to second (market-based) adjustment, which will only apply subject to the achievement of certain revenue levels.

Annual Bonus Incentive

Overview

The Company also provides executive officers with annual performance-based cash bonuses, which are specifically designed to reward executives for overall corporate performance as well as individual performance in a given year. Corporate goals are established at the beginning of each fiscal year by the Compensation Committee with input from senior management and with final approval by the independent members of the Board.Board of Directors. The target annual incentive bonus amounts vary depending on each executive’s accountability, scope of responsibilities and potential impact on the Company’s performance. Accordingly, the higher the level of control and accountability that is exercisable by an executive officer over our overall performance, the greater the percentage of the executive officer’s target total cash compensation that is dependent on the annual performance-based cash bonus award. Fiscal 20092011 target annual incentive bonus levels ranged from 30% to 50% of base salary for our named executive officers.

Our Compensation Committee sets annual incentive bonus amounts for executive officers as a percent of base salary generally ranging between the 50th50th and 75th75th percentiles in our peer group. Although the Compensation Committee has selected a target bonus in some cases above the 50th50th percentile in percentage terms, the actual total


17


cash compensation is generally expected to be at or belownear the 50th50th percentile measured in

23


dollar terms given that base salaries for most of these executive continues to be below the 50th percentile.terms. The target bonuses, as a percentage of base salary, for the named executive officers for fiscal 20102012 (excluding Mr. Sibold, who is no longer employed with the Company) are set forth in the following table.

                   
    Target Bonus
          
    for Fiscal
  Target Annual Incentive Bonus — Market Data(1) 
    2010 (% of
  25th
  50th
  75th
 
Name
 
Title
 Base Salary)  Percentile  Percentile  Percentile 
 
Keith A. Katkin President and Chief
Executive Officer
  50%  45%  50%  55%
Randall E. Kaye, MD Senior Vice President and
Chief Medical Officer
  40%  30%  35%  40%
Christine G. Ocampo Vice President, Finance  30%  20%  25%  30%
table:

      

Target
Bonus

for Fiscal

2012 (% of

  Target Annual Incentive
Bonus — Market Data(1)
 
       25th  50th  75th 

Name

  

Title

  Base Salary)  Percentile  Percentile  Percentile 

Keith A. Katkin

  President and Chief
Executive Officer
   50  50  55  60

Joao Siffert, M.D.

  Senior Vice President,

Research and Development

   40  30  35  40

Christine G. Ocampo

  Vice President, Finance   30  30  30  35

(1)Source: Radford’s Executive Compensation Review of July 2008.August 2011.

The Compensation Committee considers the individual performance of each executive officer and the Company’s overall performance for the preceding fiscal year in deciding whether to award a bonus and, if one is to be awarded, the amount of the bonus. TheFor fiscal 2011, the maximum bonus for each executive is 140%was 150% of his or her respective target and the minimum bonus, or threshold, for each executive iswas zero. All executive officers, except for the Chief Executive Officer, are assigned annual incentive bonus targets with 75% of the bonus attributed to corporate performance and 25% based on individual performance. The annual incentive bonus for the Chief Executive Officer is based 100% on overall corporate performance. In addition, the Compensation Committee has the discretion to adjust an award by +/-10%, not to exceed 140%160% of target for any bonus award, based on additional considerations of performance and to account for the evolving business environment during the performance year.

At the end of each fiscal year, individual and corporate performance are measured versus plan and a percentage of target is fixed, which then determines the size of the total bonus pool from which annual bonus incentives are to be paid to executive officers. All cash bonuses are awarded retrospectively. Payout dates for all annual incentive bonuses to executive officers are targeted during the first quarter of each fiscal year.

Fiscal 20092011 Annual Bonus Incentive

Upon completion of fiscal 2009,2011, the Compensation Committee assessed the Company’s overall performance against the achievement of corporate performance goals established in October 2008.November 2010. The Compensation Committee then assessed our Chief Executive Officer’s individual accomplishments as well as the individual accomplishments of otherthe Company’s executive officers. Performance against each goal is scored by the Compensation Committee on a scale of 10 to 5, with a score of 3 equaling the target goal and resulting in a payout amount that is equal to 100% of the target amount. Concrete and measurableAfter determining scores for individual goals, are established annually bya weighted-average score is computed, using the Compensation Committee. Actualweighting prescribed at the beginning of the year for each goal. Once a total performance is then measured against these goals and an aggregate score is determined, after factoring in a relative weightingthe funding of the goals. bonus pool is determined from the scale shown below, with the Compensation Committee retaining the discretion as set forth below to adjust individual awards, within certain limits.

Weighted Average Score

Payout Level
(Percent of Target
Amount)

0

1

2

3

4

5


0

0

50

100

125

150


24


In fixing the targets for each fiscal year, the Compensation Committee selects performance goals that are considered aggressive, meaning that they are goals that are considered achievable, but only with a high degree of diligence and success in execution. In accruing for bonuses during each fiscal year, management assumes that the target goals will be achieved (i.e., a score of 3.0), absent a set of circumstances arising during the course of the year that would suggest otherwise.

Set forth below are the general performance goals that were considered by the Compensation Committee in assessing overall performance for the 20092011 fiscal year:

year, as well as the relative weighting of these goals and the Compensation Committee’s assessment of achievement for each goal:

NUEDEXTA Commercialization (50%): This goal set targets for sales performance for NUEDEXTA and achievement of commercialization-related objectives.

NUEDEXTA Sales Performance (50%): This goal measured the net shipment revenues generated from the sales of NUEDEXTA to wholesalers and other customers along with a qualitative assessment performed by the Compensation Committee at the end of the 2011 fiscal year on the Company’s performance in executing the launch plan for NUEDEXTA. Gross NUEDEXTA GAAP revenue for 2011 fiscal year was $7.0 million, net NUEDEXTA GAAP revenue was $6.1 million, Gross NUEDEXTA shipment revenues were $8.8 million, and Net NUEDEXTA shipment revenues were $8.1 million. In scoring this goal, the Compensation Committee considered the performance of the sales force during launch and the need for the launch plan for a first-in-class product to evolve for several months to take into consideration the uncertainties of new market development. As a result, the Compensation Committee did not assign a score (effectively resulting in a score of zero “0”) for the first eight months of the 2011 fiscal year. The Compensation Committee determined that the Company’s achievement for the last four months of the 2011 fiscal year resulted in a score of 3.0 providing for a weighted average score of 1.1.

Clinical Development Goals (22.5%): These goals established target performance for the Company for the development of AVP-923 for additional indications, including submitting and receiving FDA acceptance of an Investigational New Drug application, or IND, and continuing the development of NUEDEXTA outside of the United States. The specific goals were as follows:

 

NUEDEXTA European Medicines Agency (“EMA”) Progress (12.5%):This goal measured the timely submission of a Marketing Authorization Application, or MAA, for NUEDEXTA for the PBA indication in the European Union. In September 2011, the Company was granted a full pediatric waiver from the EMA removing the Company’s requirement to conduct pediatric clinical studies in support of its MAA filing resulting in lower Company expenditures in support of its MAA filing and advancing the timeline for submission. The Company followed with filing an MAA with the EMA for NUEDEXTA for the treatment of PBA in October 2011. The Compensation Committee determined that the Company achieved a score of 4.0 for this goal.

New AVP-923 IND (10.0%): This goal measured the timely filing and acceptance of an IND application with the FDA to initiate a Phase III clinical development progresstrial of ZenviaAVP-923, an investigational drug for pseudobulbar affect (PBA) indication;the treatment of central neuropathic pain in patients with multiple sclerosis. In April 2011, the Company filed an IND application with the FDA to begin a Phase III clinical trial of AVP-923 and enrolled its first patient in the PRIME study (Pain Research in Multiple sclErosis) on November 2, 2011. The Compensation Committee determined that the Company achieved a score of 3.3 for this goal.

• Improving the intellectual property portfolio through the issuance of new patents;
• Improving the Company’s cash position by the end of the fiscal year supporting budgeted activities including resources to continue the development of Zenvia; and
• Effective

Financial Operations (20%): This category of goals focused attention on demonstrating fiscal responsibility through (i) improving the Company’s cash position by the end of the fiscal year while supporting budgeted activities such as the commercialization of NUEDEXTA; and (ii) effective budget management, as measured by expenses and working capital at the end of the fiscal year.

Fiscal 2011 Net Operating Cash Burn for Budgeted Activities (5%): The performance metric measures the Company’s aggregate cash expenditures on operations for fiscal 2011. This measure is intended to encourage efficient use of capital, while still achieving the operational goals set forth above, including

25


the commercialization of NUEDEXTA. In 2011, the Net Operating Cash Burn was approximately $64.8 million, resulting in a score of 5.0 on this goal.

Capital Raise / Cash at Year-End of Fiscal 2011 (15%): The performance metric measures the Company’s effectiveness in raising additional capital and cash available at the end of the 2011 fiscal year. This measure is intended to encourage the Company to seek and select the most efficient financing instrument(s) to appropriately fund on-going operational requirements including the commercialization of NUEDEXTA. At September 30, 2011, the Company had a cash balance of approximately $81.8 million resulting in a score of 5.0 on this goal.

Although we do not disclose specific

Corporate Development Goals (7.5%): This goal targeted enhancing the lifecycle and intellectual property estate relating to NUEDEXTA.

Portfolio Management (7.5%): This goal measures the Company’s achievement of certain corporate development objectives, including those pursued to enhance the value of the Company’s products. During the 2011 fiscal year, the Company defined a corporate development strategy that is expected to enhance the overall business relating to NUEDEXTA with plans on initiating and/or executing on one or more strategic initiatives during the 2012 fiscal year. The Compensation Committee awarded a score of 3.0 for this goal based on the Company’s thorough diligence and assessment of several corporate development opportunities and the Company’s efforts in establishing a long-term lifecycle strategy expected to enhance the intellectual property estate of the Company’s product portfolio.

The individual performance goals for competitive reasons, we believe thatKeith A. Katkin, the Company’s Chief Executive Officer, were the same as the overall corporate performance goals discussed above provide our stockholders with an understandingfor the Company, as the primary responsibility of the keyChief Executive Officer is to help ensure the overall success of the Company by executing the Company’s business strategies. All other executive officers are assigned annual incentive bonus targets with 75% of the bonus attributed to corporate events consideredperformance and 25% based on individual performance. The individual goals for Dr. Siffert and Ms. Ocampo are discussed below. In addition, as described above, the Compensation Committee has the discretion to adjust an award by +/-10%, not to exceed 160% of target for any bonus award, based on additional considerations of performance, significant achievements not covered by the annual goals as established at the beginning of the year, and to account for the evolving business environment during the performance year.

The individual performance goals for Joao Siffert, the Company’s Senior Vice President, Research and Development, and Christine Ocampo, the Company’s Vice President of Finance, were similar to the overall corporate performance goals but weighted more heavily, in Dr. Siffert’s case, to clinical development and regulatory milestones, and in Ms. Ocampo’s case, to cash position and budgetary matters, consistent with their roles and responsibilities at the Company. Specifically, the clinical development and regulatory goals described above under the captions “NUEDEXTA EMA Progress” and “New AVP-923 IND” accounted for 100% of Dr. Siffert’s individual performance goals. With respect to Ms. Ocampo, the financial operations goals described above accounted for 30% of her individual performance goals. The other 70% of Ms. Ocampo’s individual performance goals for fiscal 2011 related to building a finance team and expanding the capabilities of the finance department in support of the commercialization of NUEDEXTA (30%), corporate financial leadership (25%), and management of compliance areas, including complying with the requirements of the Sarbanes-Oxley Act and establishing a commercial compliance program (15%). Dr. Siffert’s and Ms. Ocampo’s level of achievement for individual goals is determined by the Compensation Committee, based in assessing performance inpart on recommendations from the last fiscal year.


18


In particular,Chief Executive Officer, with respect to achieving progress towardinput from the overall strategic objectives noted above,Chairman of the Audit Committee, who is also a member of the Compensation Committee noted the following key accomplishments during the review period:
• Announcement of positive Phase III study results for Zenvia;
• Achievement of several accelerated patient enrollment milestones for the STAR Trial; and
• Effective budget and cash management.
Committee.

Achievement of Goals and Relationship to Compensation Awarded

For fiscal 2009,2011, the Compensation Committee determined that the Company’s performance against the corporate performance goals established in October 2008 merited a score of 3.82.58 out of 5.0, resulting in a bonus pool equal to 116% of the target amount. The bonus pool was calculated by applying the scale of 1 to 5 previously established in the Company’s annual bonus plan guidelines, with a score of 3.0 resulting in a payout amount of 100%79% of the target amount and a score of 5.0 resulting infor corporate achievement. Upon determining the maximum payout amount of 140% ofCompany’s performance against the target amount. In addition,corporate

26


performance goals, the Compensation Committee applied its discretion within the guidelines ofto adjust the Company’s annualcorporate achievement score to 2.5 out of 5.0, resulting in a downward adjustment of 4% to set the corporate achievement bonus plan, and approved adjustmentspool to individual75% of target. With respect to Mr. Katkin, his bonus award amounts for each executive officer in consideration ofwas determined solely based on the Company’s additional key accomplishmentsperformance against the corporate goals. The Compensation Committee determined that Dr. Siffert and Ms. Ocampo achieved individual scores of 3.65 out of 5.0 and 3.85 out of 5.0, respectively, resulting in weighted-average annual performance scores of 2.79 for fiscal 2009.

In November 2009,Dr. Siffert and 2.84 for Ms. Ocampo.

These levels of achievement for the combined corporate and individual goals resulted in the Compensation Committee approvedapproving bonus awards for performance in 2011 as set forth in the following bonus awards:

       
    Bonus for
 
Name
 
Title
 Fiscal 2009 
 
Keith A. Katkin President and Chief Executive Officer $235,146 
Randall E. Kaye, MD Senior Vice President and Chief Medical Officer $165,000 
Christine G. Ocampo Vice President, Finance $75,963 
table:

Name

  

Title

  Fiscal 2011 

Keith A. Katkin

  President and Chief Executive Officer  $185,925  

Joao Siffert, M.D.

  Senior Vice President, Research and Development  $118,475 (1) 

Christine G. Ocampo

  Vice President, Finance  $57,173  

(1)Pursuant to Dr. Siffert’s employment offer letter, his bonus award was prorated for the 2011 fiscal year and based on a 9-month period.

Equity Compensation

Overview

Overview

Stock Options and Restricted Stock. As an additional component of our compensation program, executive officers are eligible to receive equity compensation in the form of stock options or restricted stock awards, which may also be granted as awards of restricted stock units. The Compensation Committee grants stock options to executive officers to aid in their retention, to motivate them to assist with the achievement of corporate objectives and to align their interests with those of our stockholders by creating a return tied to the performance of our stock price. In determining the form, date of issuance and value of a grant, the Compensation Committee considers the contributions and responsibilities of each executive officer, appropriate incentives for the achievement of our long-term growth, the size and value of grants made to other executives at peer companies holding comparable positions, individual achievement of designated performance goals, and the Company’s overall performance relative to corporate objectives.

Under the terms of our 2003 Equity Incentive Plan and our 2005 Equity Incentive Plan, pursuant to which all new equity grants are currently made, the exercise price of any stock options awarded under these plans must be equal to at least 100% of the fair market value of our common stock (the closing sales price on the NASDAQ Global Market) on the date of grant. We do not have any program, plan or obligation that requires us to grant equity awards on specified dates, although historically we have made annual grants to existing officers and employees two full trading days after our initial release of year-end earnings results, to new hires on a fixed schedule within one month of the commencement of their employment, and periodically in connection with broader compensation surveys. We also do not have any program, plan or practice to time stock option grants to our executive officers in coordination with the release of material nonpublic information, other than our practice to grant optionsissue annual option awards two full trading days after our publicinitial release of year-end earnings results. Equity awards may occasionally be granted following a significant change in job responsibilities or to meet other special retention or performance objectives. Additionally, executive officers are eligible to receive equity compensation in the form of restricted stock awards, which may also be granted as awards of restricted stock units.

Authority to make equity grants to employees rests with the Compensation Committee. With respect to executive officers, recommendations for equity grants are made by our external compensation consultant, Radford, and then reviewed by the Chief Executive Officer before being sent to the Compensation Committee for review and consideration. The Compensation Committee Chairman has been delegated the authority to review and approve rewards to non-officer employees, within limits set by the Compensation Committee.

In addition, the Chief Executive Officer has been delegated the authority to review and approve new hire awards if they are consistent with the guidelines approved by the Compensation Committee.

27


We believe that periodic equity awards serve as useful performance recognition mechanisms with respect to key employees, as most awards are subject to time-based vesting provisions. Our typical equity awards to executive officers (including the named executive officers) have a term of 10 years and vest and become exercisable over a


19


period of four years, with 25% of the underlying shares vesting on the first anniversary of the grant date and the remainder quarterly over the next three years. Occasionally the granting or vesting of an equity award may be made contingent on achievement of certain specific performance conditions. We believe that such periodic equity awards encourage executive officers to remain with the Company and also focus on our long-term performance as well as the achievement of specific performance goals.

Equity Grants Awarded and to be Awarded in Fiscal 20092012

In July 2008, following a complete review by Radfordconsideration of the Company’s executive compensation program,overall performance against the achievement of corporate goals for fiscal 2011, in November 2011 the Compensation Committee approved a one-time performance-based grant to adjustannual equity ownership towards market competitive levels, targeted at the 50th percentile. Radford’s assessment concluded that the majority of equity holdings byawards for the Company’s executive officers who were expectedand employees. These annual equity awards have historically been awarded to serveexisting officers and employees two full trading days after our initial release of year-end earnings results. For the Company for at least2012 fiscal year, the next several years had minimal value, which gave riseCompensation Committee approved granting annual equity awards, consistent with the recommendations presented by Radford in August 2011, representing a mix of stock options and full-value restricted stock units to concerns in retaining the Company’s executives. The grant was tied to performance milestones primarily centered onexecutive officers at the 50th percentile level of the Company’s Phase III program for Zenviaequity guidelines respective of each executive officer’s grade level. The Company’s equity guidelines are based on recommendations by Radford using market data regarding long-term incentives and equity compensation from the Company’s list of new peer companies. The Compensation Committee works directly with Radford and the Chairman of the Board to determine the annual equity award for the pseudobulbar affect (PBA) indication.Chief Executive Officer. All annual equity awards under the one-time performance-based grant were awarded duringgranted in fiscal 2009 following the achievement2012 to executive officers, including Chief Executive Officer, have a term of those performance milestones. The performance grants began vesting10 years and vest and become exercisable over a period of four years, with respect to 6.25%25% of the underlying shares followingvesting on the achievement of eachfirst anniversary of the performance milestonesgrant date and the remainder quarterly over the next fifteen quarters, thus continuingthree years.

In addition to provide value after the vesting milestones by inducing the executives to remain employed with the Company.

The values of theannual equity grantsgrant awarded to executive officers in fiscal 2009 as well as all compensation actions issued to the named executive officers in fiscal 2009 are reflected in the Summary Compensation Table.
Amendment to Restricted Stock Unit Vesting Schedule in Fiscal 2009
In June 2009, in anticipation of the vesting of the restricted stock unit awards granted to the executive officers and other members of senior management in March 2007,2012, the Compensation Committee approved an amendmenta performance-based grant in the form of restricted stock units, the vesting of which commences following the achievement of certain revenue levels during the 2012 fiscal year. The performance-based grant is intended to promote executive retention, while tying compensation to the vesting schedulecreation of meaningful stockholder value in a fashion that is consistent with the Company’s pay-for-performance philosophy. The performance-based grants will be granted at the same time as the annual equity awards, two full trading days after our initial release of year-end earnings results. The actual number of shares underlying these performance-based awards will be determined based on the actual achievement of the awards, subject to obtainingrevenue goal in fiscal 2012. Once the consentgoal is achieved, the number of shares underlying the awardee. The restricted stock unit awards were granted in March 2007, with one-half ofaward will be fixed and the awards to vest on the third anniversary of the grant date, March 2010, and one-half to vest upon the FDA’s acceptance of Company’s NDA for Zenvia for PBA, which is currently expected to occur early in the second calendar quarter of 2010. In consideration of the financial implications to the awardees to satisfy withholding obligations upon vesting of the awards, the Compensation Committee approved amending the vesting schedule of the awards to a fixed time-based vesting schedule,will commence, vesting over a period of four years, with 25% of the awardsunderlying shares vesting on each of July 15, 2009, January 4, 2010, April 30, 2010, and August 31, 2010. The amended vesting schedule was not expected to materially change the overall vesting timing and would result in the complete vesting of the awards on August 31, 2010, meaning that there would be no deferralfirst anniversary of the vesting beyondcommencement date and the tax year in whichremainder quarterly over the awards were originally expected to vest.
next three years.

Employee Benefit Program

Executive officers are eligible to participate in all of our employee benefit plans, including medical, dental, vision, group life, disability and accidental death and dismemberment insurance, in each case on the same basis as other employees, subject to applicable law. We also provide vacation and other paid holidays to all employees, including executive officers, all of which we believe to be comparable to those provided at peer companies. These benefit programs are designed to enable us to attract and retain our workforce in a competitive marketplace. Health, welfare, and vacation benefits ensure that we have a productive and focused workforce through reliable and competitive health and other benefits.

Our retirement savings plan (401(k) Plan) is a tax-qualified retirement savings plan, pursuant to which all employees, including the named executive officers, are able to contribute certain amounts of their annual compensation, subject to limits prescribed by the Internal Revenue Service. We make matching contributions of up to 50% of the first 4% of salary contributed to the plan. The value of these benefits for each of our named executive officers is reflected in the “All Other Compensation” column of the Summary Compensation Table.

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Change of Control Arrangements

We have entered into change of control agreements with each of our named executive officers. Our Board of Directors approved these change of control agreements in order to mitigate some of the risk that exists for executives working in a biopharmaceutical company at our current stage of development and where the possibility exists that we may be acquired if our development efforts succeed. These arrangements are intended to retain highly skilled executives who have alternatives that may appear to them to be less risky absent these arrangements and to mitigate a potential


20


disincentive to consider and complete an acquisition, particularly where the services of these executive officers may not be required by the acquirer. These agreements provide change of control benefits either upon the termination of the employee’s service, a significant change in job responsibilities or the need to relocate within 12 months following a change of control. By using a so-called “double trigger” change of control benefit, and thereby tying the severance benefit both to a change in control and change in job status, rather than the mere consummation of a change of control transaction, the Compensation Committee believes that it is better able to balance the employee’s need for certainty with the interests of our stockholders.

Additionally, our named executive officers may be entitled to acceleration benefits under stock option and equity incentive plans. Our 2003 Equity Incentive Plan contains certain acceleration benefits providing for the accelerated vesting of equity awards in the event of a change of control if such awards are not assumed or substitute awards are issued. Our 2005 Equity Incentive Plan contains similar provisions, as well as a “double trigger” acceleration benefit that applies if services are terminated for certain reasons within 12 months following a change of control. We believe that these “double trigger” acceleration benefits are common practice among comparable companies.

Information regarding the change of control agreements and the potential value of payments upon termination or change of control is provided for the named executive officers under the headings “Employment, Change of Control and Severance Arrangements” and “Potential Payments Upon Termination or Change of Control.”

Compensation of our Current Named Executive Officers

Keith Katkin. Mr. Katkin is compensated with a base salary and, depending on performance and our financial condition, an annual incentive bonus in an amount targeted at 50% of his then-current annual base salary, as well as the annual grant of an equity award. In November 2009,2011, his base salary was increased by 9.9%2.0% to $410,199,$505,716, effective as of October 1, 2009. This change in base salary represents2011, representing a 3.0% merit-based increase for fiscal 2009 and2011 performance. In addition, Mr. Katkin is eligible to receive an additional 6.9% merit-based5.0% increase that was awarded uponfollowing the achievement of a certain revenue level during the 2012 fiscal year. This additional base salary increase is consistent with the decision made by the Compensation Committee’s approvalCommittee in 2010 to adjust base salaries over a three-year period, starting in fiscal 2011, for the Company’s executive officers to competitive levels at or near the 50th percentile as compared to the Company’s new peer group. The potential total change in Mr. Katkin also received an optionKatkin’s base salary, including the merit-based increase and salary adjustment, is expected to purchase 689,700 shares of common stock followingraise his base compensation between the achievement25th and 50th percentile of the performance milestones established as part of the performance-based grants approved by the Compensation Committee in July 2008. These performance grants began vesting with respect to 6.25% of the underlying shares following the achievement of each of the performance milestones and the remainder quarterly over the next fifteen quarters. Additionally, on November 27, 2009,new peer group. On December 15, 2011, two trading days after our publicinitial release of year-end earnings results, Mr. Katkin received an annual equity award representing a mix of stock options and full-value restricted stock units, in which he received an option to purchase 417,600 additional337,500 shares of common stock and a grant of 30,000 restricted stock units, which will vest and become exercisable over a period of four years, with 25% of the underlying shares vesting on the first anniversary of the grant date and the remainder quarterly over the next three years.

In addition, Mr. Katkin was awarded on December 15, 2011 a performance-based grant of a restricted stock unit representing the right to receive up to 97,000 shares of common stock. The grant is tied to a performance milestone relating to the achievement of certain revenue levels during the 2012 fiscal year, with the actual number of shares underlying the award to be determined following the achievement of the performance milestone. This grant will vest and become exercisable over a period of four years, with 25% of the underlying shares vesting on the first anniversary of the vesting commencement date and the remainder quarterly over the next three years.

Randall Kaye.Joao Siffert, M.D. Dr. Kaye,Siffert, our Senior Vice President of Research and Chief Medical Officer,Development, is compensated with a base salary and, depending on performance and our financial condition, an annual incentive bonus in an amount

29


targeted at 40% of his then-current annual base salary. In November 2009, Dr. Kaye’s2011, his base salary was increased by 3.0%2.75%, prorated based on the start of his employment with the Company, to $336,467,$351,604, effective as of October 1, 2009, in2011, representing a merit-based increase for fiscal 2009. Dr. Kaye also received an option to purchase 271,700 shares of common stock following the achievement of the performance milestones established as part of the performance-based grants approved by the Compensation Committee in July 2008. These performance grants began vesting with respect to 6.25% of the underlying shares following the achievement of each of the performance milestones and the remainder quarterly over the next fifteen quarters. Additionally, on November 27, 2009,2011 performance. On December 15, 2011, two trading days after our publicinitial release of year-end earnings results, Dr. KayeSiffert received an annual equity award representing a mix of stock options and full-value restricted stock units, in which he received an option to purchase 210,900 additional56,250 shares of common stock and a grant of 8,125 restricted stock units, which will vest and become exercisable over a period of four years, with 25% of the underlying shares vesting on the first anniversary of the grant date and the remainder quarterly over the next three years.

In addition, Dr. Siffert was awarded on December 15, 2011 a performance-based grant of a restricted stock unit representing the right to receive up to 21,375 shares of common stock. The grant is tied to a performance milestone relating to the achievement of certain revenue levels during the 2012 fiscal year, with the actual number of shares underlying the award to be determined following the achievement of the performance milestone. This grant will vest and become exercisable over a period of four years, with 25% of the underlying shares vesting on the first anniversary of the vesting commencement date and the remainder quarterly over the next three years.

Christine Ocampo. Ms. Ocampo, our Vice President of Finance, is compensated with a base salary and, depending on performance and our financial condition, an annual incentive bonus in an amount targeted at 30% of her then-current annual base salary. In November 2009,2011, her base salary was increased by 6.5%2.0% to $210,678,$224,562, effective as of October 1, 2009. This change in base salary represents2011, representing a 3.0% merit-based increase for fiscal 2009 and2011 performance. In addition, Ms. Ocampo is eligible to receive an additional 3.5% merit-based5.5% increase that was awarded uponfollowing the achievement of a certain revenue level during the 2012 fiscal year. This additional base salary increase is consistent with the decision made by the Compensation Committee’s approvalCommittee in 2010 to adjust base salaries over a three-year period, starting in fiscal 2011, for the Company’s executive officers to competitive levels at or near the 50th percentile as compared to the Company’s new peer group. The potential total change in Ms. Ocampo also received an optionOcampo’s base salary, including the merit-based increase and salary adjustment, is expected to purchase 167,200 shares of common stock followingraise her base compensation to the achievement25th percentile of the performance milestones established as part of the performance-


21


based grants approved by the Compensation Committee in July 2008. These performance grants began vesting with respect to 6.25% of the underlying shares following the achievement of each of the performance milestones and the remainder quarterly over the next fifteen quarters. Additionally, on November 27, 2009,new peer group. On December 15, 2011, two trading days after our publicinitial release of year-end earnings results, Ms. Ocampo received an annual equity award representing a mix of stock options and full-value restricted stock units, in which she received an option to purchase 153,400 additional90,000 shares of common stock and a grant of 6,250 restricted stock units, which will vest and become exercisable over a period of four years, with 25% of the underlying shares vesting on the first anniversary of the grant date and the remainder quarterly over the next three years.
In addition, Ms. Ocampo was awarded on December 15, 2011 a performance-based grant of a restricted stock unit representing the right to receive up to 13,750 shares of common stock. The grant is tied to a performance milestone relating to the achievement of certain revenue levels during the 2012 fiscal year, with the actual number of shares underlying the award to be determined following the achievement of the performance milestone. This grant will vest and become exercisable over a period of four years, with 25% of the underlying shares vesting on the first anniversary of the vesting commencement date and the remainder quarterly over the next three years.

William J. Sibold. Mr. Sibold, our former Senior Vice President and Chief Commercial Officer, was compensated with a base salary and was deemed ineligible to receive any annual incentive award, or any other year-end compensation tied to the Company’s performance during the 2011 fiscal year, due to his resignation of employment with the Company on November 16, 2011.

Tax and Accounting Considerations

Deductibility of Executive Compensation. In making compensation decisions affecting our executive officers, the Compensation Committee considers our ability to deduct under applicable federal corporate income tax law compensation payments made to executives. Specifically, the Compensation Committee considers the requirements and impact of Section 162(m) of the Internal Revenue Code, which limits the tax deductibility to us of compensation in excess of $1.0 million in any year for certain executive officers, except for qualified “performance-based compensation” under the Section 162(m) rules. The Compensation Committee considers the Section 162(m) rules as a factor in determining compensation, but will not necessarily limit compensation to amounts deductible under Section 162(m). No covered executive’s compensation for Section 162(m) purposes exceeded $1.0 million for fiscal 2009.

2011.

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Accounting for Stock-BasedShare-Based Compensation. Effective October 1, 2005, we adoptedIn accordance with the fair value recognition provisions of SFAS No. 123(R) to account for all stock grants under all of our stock plans. Under SFAS No. 123(R),Financial Accounting Standards Board’s Accounting Standards Codification 718, we are required to estimate and record an expense at the measurement datevalue for each award of equity compensation at the measurement date using the fair value method and record an expense over the vestingservice period of the award. Accounting rules also require us to record cash compensation as an expense at the time the obligation is incurred.

Allocation of Compensation

There is no pre-established policy or target for the allocation of compensation. The factors described above, as well as the overall compensation philosophy, are reviewed to determine the appropriate level and mix of compensation. Historically, and inIn fiscal 2009,2011, the largest portion of compensation to named executive officersMr. Katkin, Dr. Siffert, Ms. Ocampo, and Mr. Sibold was granted in the form of base salary.

equity compensation.

Timing of Compensation Actions

Compensation, including base salary adjustments, for our named executive officers is reviewed annually, usually in the first quarter of the fiscal year and upon promotion or other change in job responsibilities.

Minimum Stock Ownership Requirements

There are no minimum stock ownership guidelines for our executives or employees, although senior members of our management team are encouraged and expected to have a significant direct interest in the value of our common stock through open market purchasesand/or receipt of equity awards.

Conclusion

Our compensation policies are designed and are continually being developed to retain and motivate our executive officers and to reward them for outstanding individual and corporate performance.

Compensation Committee Report

The Compensation Committee of the Company has reviewed and discussed with management the Compensation Discussion and Analysis required by Item 402(b) ofRegulation S-K. Based on this review and discussion, the Compensation Committee recommended to the Board of Directors that the foregoing Compensation Discussion and Analysis be included in this proxy statement.

Submitted by the Compensation Committee of the
Board of Directors

David J. Mazzo, Ph.D., Chairman

David J. Mazzo, Ph.D., Chairman

Dennis G. Podlesak

Stephen G. Austin, CPA


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Summary Compensation Table

The following table summarizes compensation paid, awarded or earned for services rendered during fiscal 20082009, 2010 and 20092011 by our President and Chief Executive Officer, our Senior Vice President, Research and Chief Medical Officer andDevelopment, our Vice President, Finance.Finance and our former Senior Vice President and Chief Commercial Officer. We refer to these executive officers collectively as our “named executive officers.”

                             
        Non-Equity
             
        Plan
             
Name and
 Fiscal
     Performance
  Option
  Stock
  All Other
    
Principal Position
 Year  Salary  Awards(1)  Awards(2)  Awards(2)  Compensation(3)  Total 
 
Keith A. Katkin  2009  $373,248  $235,146  $374,144  $290,797  $19,993  $1,293,328 
President and Chief Executive Officer  2008   343,544   210,568   302,726   266,843   21,716   1,145,397 
Randall E. Kaye, M.D.  2009   326,667   165,000   149,481   218,006   31,350   890,504 
Senior Vice President and Chief Medical Officer  2008   317,117   155,496   101,870   226,311   27,814   828,608 
Christine G. Ocampo  2009   197,820   75,963   40,264   31,596   13,753   359,396 
Vice President, Finance  2008   170,848   62,878   9,546   26,056   16,810   286,138 

        Non-Equity             
        Plan             
Name and Fiscal     Performance  Option  Stock  All Other    

Principal Position

 Year  Salary  Awards(1)  Awards(2)  Awards(2)  Compensation(3)  Total 

Keith A. Katkin

  2011   $495,800   $185,925   $1,368,640   $261,250   $24,023   $2,335,638  

President and Chief

  2010   $410,199   $307,649   $581,383   $—     $24,729   $1,323,960  

Executive Officer

  2009   $373,248   $235,146   $178,515   $—     $19,993   $806,902  

Joao Siffert, M.D. (4)

  2011   $56,731   $89,578   $579,306   $—     $7,377   $732,992  

Senior Vice President,

       

Research and Development

       

Christine G. Ocampo

  2011   $220,159   $57,173   $248,066   $47,025   $18,288   $590,711  

Vice President, Finance

  2010   $210,678   $94,805   $213,563   $—     $14,204   $533,250  
  2009   $197,820   $75,963   $51,987   $94,875   $13,753   $434,398  

William J. Sibold (4)

  2011   $154,808   $—     $850,325   $83,400   $9,664   $1,098,197  

Former Senior Vice President and Chief Commercial Officer

       

(1)Annual bonuses are presented as “non-equity plan performance awards.” Such amounts are determined and paid after the end of each fiscal year, but reflect individual and Company performance for the respective fiscal years reflected above.

(2)The valuesThis column reflects the aggregate grant date fair value of the option and stockequity awards summarizedgranted in the table for each of fiscal years2011, 2010 or 2009 and 2008 have been computedcalculated in accordance with SFAS No. 123(R), which requires that we recognize as compensation expenseFASB ASC 718, excluding the valueeffect of all stock-based awards, including stock options, granted to employees in exchange for their services over the requisite service period, which is typically the vesting period, but excluding forfeiture assumptions that are used in calculating equity award expense in the Company’s financial statements.estimated forfeitures. Assumptions used in the calculations for these amounts are includedset forth in Note 12the notes to our 2009 Consolidated Financial Statementsfinancial statements included in our Annual ReportReports onForm 10-K for each of the fiscal year ended September 30, 2009 and Note 13 to our 2008 Consolidated Financial Statements included in our Annual Report onForm 10-K for the fiscal year ended September 30, 2008.periods presented above.

(3)“All Other Compensation” summarized in the table for fiscal 2011 for Mr. Katkin consists of $19,123 in medical, dental, vision, disability and life insurance premiums paid by us and $4,900 in matching contributions made by us under our 401(k) Plan. “All Other Compensation” summarized in the table for fiscal 2010 for Mr. Katkin consists of $19,829 in medical, dental, vision, disability and life insurance premiums paid by us and $4,900 in matching contributions made by us under our 401(k) Plan. “All Other Compensation” summarized in the table for fiscal 2009 for Mr. Katkin consists of $14,831 in medical, dental, vision, disability and life insurance premiums paid by us and $5,162 in matching contributions made by us under our 401(k) Plan. “All

“All Other Compensation” summarized in the table for fiscal 2011 for Dr. Siffert consists of $6,838 in health savings account contributions and medical, dental, vision, disability and life insurance premiums paid by us and $539 in matching contributions made by us under our 401(k) Plan.

“All Other Compensation” summarized in the table for Ms. Ocampo consists of medical, dental, vision, disability and life insurance premiums paid by us in the amount of $18,288 for fiscal 2011, $14,204 for fiscal 2010 and $13,753 for fiscal 2009.

“All Other Compensation” summarized in the table for fiscal 2011 for Mr. Sibold consists of $7,241 in medical, dental, vision, disability and life insurance premiums paid by us and $2,423 in matching contributions made by us under our 401(k) Plan.

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(4)This person was not a named executive officer prior to fiscal 2011. Therefore, compensation information for years prior to fiscal 2011 is not required.

Grants of Plan-Based Awards

The following table sets forth certain information regarding grants of plan-based awards to the named executive officers during fiscal 2011.

Name

  Grant
Date
   Performance  Stock
Awards:
Number of
Shares of
Stock or Units
Granted

(#)
  Option
Awards:
Number of
Securities
Underlying
Options
Granted
(#)(1)
   Exercise
Price of
Option
Awards
($/Sh)
   Grant Date
Fair Value of
Stock and
Option
Awards($)(2)
 

Keith A. Katkin

   12/1/2010     62,500 (3)   400,000    $4.18    $1,629,890  

Joao Siffert, M.D.

   9/6/2011     —      260,000    $2.74    $579,306  

Christine G. Ocampo

   12/1/2010     11,250 (3)   72,500    $4.18    $295,091  

William J. Sibold

   5/3/2011     20,000 (4)   250,000    $4.17    $933,725  

(1)Options vest with respect to one quarter of the underlying shares on the first anniversary of the grant date, and then with respect to the remaining shares on a quarterly basis over the next three years so that the option is fully vested on the fourth anniversary of the grant date.

(2)This column reflects the aggregate grant date fair value of equity awards granted in 2011 and calculated in accordance with FASB ASC 718, excluding the effect of estimated forfeitures. Assumptions used in the tablecalculations for fiscal 2008 for Mr. Katkin consists of $17,056 in medical, dental, vision, disability and life insurance premiums paid by us and $4,660 in matching contributions made by us under our 401(k) Plan.
“All Other Compensation” summarizedthese amounts are set forth in the tablenotes to our financial statements included in our Annual Report on Form 10-K for the fiscal 2009 for Dr. Kaye consists of $26,251 in medical, dental, vision, disability and life insurance premiums and reimbursements paid by us and $5,099 in matching contributions made by us under our 401(k) Plan. “All Other Compensation” summarized in the table for fiscal 2008 for Dr. Kaye consists of $24,016 in medical, dental, vision, disability and life insurance premiums and reimbursements paid by us and $3,798 in matching contributions made by us under our 401(k) Plan.
“All Other Compensation” summarized in the table for fiscal 2009 for Ms. Ocampo consists of $13,753 in medical, dental, vision, disability and life insurance premiums paid by us. “All Other Compensation” summarized in the table for fiscal 2008 for Ms. Ocampo consists of $16,810 in medical, dental, vision, disability and life insurance premiums paid by us.year ended September 30, 2011.


23

(3)Stock awards vest with respect to 50% of the underlying shares on the first anniversary of the grant date, and then with respect to the remaining 50% of the underlying shares on the second anniversary of the grant date.

(4)Stock award vests with respect to one quarter of the underlying shares on the first anniversary of the grant date, and then with respect to the remaining shares on a quarterly basis over the next three years so that the award is fully vested on the fourth anniversary of the grant date.


Outstanding Equity Awards at Fiscal Year-End

The following table shows information regarding outstanding equity awards at September 30, 20092011 for our named executive officers.

                         
  Option Awards  Stock Awards 
                 Market
 
              Number
  Value of
 
              of Shares
  Shares or
 
        Option
     or Units
  Units of
 
  Number of Securities
  Exercise
  Option
  of Stock that
  Stock that
 
  Underlying Unexercised Options  Price
  Expiration
  Have Not Vested
  Have Not
 
Name
 Exercisable  Unexercisable  ($)  Date  (#)  Vested ($)(1) 
 
Keith A. Katkin  75,000     $11.76   7/5/15   18,000(2) $37,440 
   7,500     $11.68   12/7/15   39,844(3) $82,876 
      130,960(4) $1.29   3/21/17   354,892(3) $738,175 
      120,781(4) $2.41   9/10/17     $ 
   80,232   609,468(5) $0.88   7/25/15     $ 
      446,400(2) $0.53   12/16/18     $ 
Randall E. Kaye, M.D.   32,813   4,687(2) $15.84   1/17/16   18,000(2) $37,440 
   31,607   240,093(5) $0.88   7/25/15   187,500(3) $390,000 
      185,000(2) $0.53   12/16/18   107,143(4) $222,857 
Christine G. Ocampo  12,500   7,500(2) $1.20   3/29/17   57,500(4) $119,600 
   19,450   147,750(5) $0.88   7/25/15     $ 
      130,000(2) $0.53   12/16/18     $ 

  Option Awards  Stock Awards 
  Number of Securities
Underlying Unexercised
Options
  Option
Exercise
Price
($)
  Option
Expiration
Date
  Number
of  Shares
or Units
of Stock that
Have Not Vested
(#)
  Market
Value of
Shares or
Units of
Stock that
Have Not
Vested ($)(1)
 

Name

 Exercisable  Unexercisable     

Keith A. Katkin

  75,000    —     $11.76    7/5/15    62,500 (2)  $178,750  
  7,500    —     $11.68    12/7/15    —     $—    
  130,960    —     $1.29    3/21/17    —     $—    
  120,781    —     $2.41    9/10/17    —     $—    
  425,082    264,618   $0.88    7/25/18    —     $—    
  111,600    139,500   $0.53    12/16/18    —     $—    
  182,700    234,900   $1.74    11/27/19    —     $—    
  —      400,000   $4.18    12/1/20    —     $—    

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  Option Awards  Stock Awards 
  Number of Securities
Underlying Unexercised
Options
  Option
Exercise
Price
($)
  Option
Expiration
Date
  Number
of  Shares
or Units
of Stock that
Have Not Vested
(#)
  Market
Value of
Shares or
Units of
Stock that
Have Not
Vested ($)(1)
 

Name

 Exercisable  Unexercisable     

Joao Siffert, M.D.

  —      260,000   $2.74    9/6/21    —     $—    

Christine G. Ocampo

  3,750    —     $1.20    3/29/17    11,250 (2)  $32,175  
  82,050    64,150   $0.88    7/25/18    —     $—    
  89,375    40,625   $0.53    12/16/18    —     $—    
  28,763    86,287   $1.74    11/27/19    —     $—    
  —      72,500   $4.18    12/1/21    —     $—    

William J. Sibold

  —      250,000   $4.17    5/3/21    20,000 (3)  $57,200  

(1)Calculated by multiplying the number of unvested shares by $2.08,$2.86, the closing price per share of our common stock on the NASDAQ Global Market on September 30, 2009.2011.

(2)The total award vests 50% on the first anniversary of the date of grant and the remaining 50% on the second anniversary of the grant date.

(3)The total award vests over four years, with 25% vesting on the first anniversary of the date of grant and the remainder vesting quarterly thereafter over the next three years.

Option Exercises and Stock Vested

The following table sets forth the vesting in fiscal 2011 of shares of restricted stock or restricted stock units held by the named executive officers, as well as the options exercised by our named executive officers during fiscal 2011.

   Option Awards   Stock Awards 
       Value       Value 
   Number of Shares   Realized   Number of Shares   Realized 
Name and  Acquired on   on Exercise   Acquired on   on Vesting 

Principal Position

  Exercise (#)   ($)(1)   Vesting (#)   ($)(1) 

Keith A. Katkin

   195,300    $693,745     3,600    $14,103  

Joao Siffert, M.D.

   —      $—       —      $—    

Christine G. Ocampo

   47,350    $119,052     28,750    $114,138  

William J. Sibold

   —      $—       —      $—    

(3)(1)The total award was grantedRepresents the difference, if positive, between the fair value of the underlying common stock on March 21, 2007 and vests equally over four vest dates, with the first vest date being July 15, 2009of vesting and the last vest date being August 31, 2010.
(4)The total award was granted on December 4, 2007 and vests equally over two vest dates, with the first vest date being March 15, 2010 and the last vest date being December 4, 2010.
(5)The total award is comprised of three grants each related to the achievement of performance goals, which were met in fiscal 2009. Each grant vests over three and3/4 years, with one-sixteenth of each grant vesting on the achievementexercise price of the performance goal and the remainder vesting quarterly thereafter over the next three and1/2 years.award (if any); stock awards (granted as restricted stock units) do not have an exercise price.

Pension Benefits

We do not have a defined benefit plan. Our named executive officers did not participate in, or otherwise receive any special benefits under, any pension or defined benefit retirement plan sponsored by us during fiscal 2009.

2011.

Nonqualified Deferred Compensation

During fiscal 2009,2011, our named executive officers did not contribute to, or earn any amount with respect to, any defined contribution or other plan sponsored by us that provides for the deferral of compensation on a basis that is not tax-qualified.

Employment, Change of Control and Severance Arrangements

We have entered into employment agreements with each of the named executive officers. These agreements set forth the individual’s base salary, bonus compensation, equity compensation and other employee benefits, which are

34


described above in the Compensation Discussion and Analysis. All employment agreements provide for “at-will” employment, meaning that either party can terminate the employment relationship at any time, although our


24


agreements with our named executive officers provide that they would be eligible for severance benefits in certain circumstances following a termination of employment without cause. These arrangements are described below.

Change of Control Agreements. We have entered into change of control agreements with each of our currentnamed executive officers. The change of control agreements provide certain severance benefits to each officer if his or her employment is terminated within 12 months following a “change of control,” which shall have occurred if (i) any person or entity, including a group deemed to be a person under Section 14(d)(2) of the Exchange Act, becomes the “Beneficial Owner” (as defined inRule 13d-3 under the Exchange Act) of securities of the Company representing 50% or more of the combined voting power of the Company’s securities entitled to vote in the election of directors of the Company; or (ii) as a result of or in connection with a proxy solicitation made by a third party pursuant to Regulation 14A of the Exchange Act, the individuals who were our directors immediately before the election cease to constitute a majority of the Board; or (iii) there occurs a reorganization, merger, consolidation or other corporate transaction to which we are a party and in which our stockholders immediately prior to such transaction do not, immediately after such transaction, own more than 50% of the combined voting power of the Company; or (iv) all or substantially all of the assets of the Company are sold, liquidated or distributed, other than in connection with a bankruptcy, insolvency or other similar proceeding, or an assignment for the benefit of creditors.

These severance benefits will be paid only if (i) the termination of employment occurs subsequent to the signing of an agreement, the consummation of which would result in a change of control, or within 12 months following the change of control, and (ii) the termination was without “cause” or was a “resignation for good reason” (as such terms are defined). If these conditions are met for a particular officer, he or she will receive severance payments equal to either 12 months (for Vice Presidents), 18 months (for Ms. Ocampo) or 24 months (for Senior Vice Presidents and above) of base salary, plus an amount equal to the greater of (A) the aggregate bonus payment(s) received by such officer in the Company’s preceding fiscal year or (B) the officer’s then-current target bonus amount.amount; provided, however, that if the officer ceases to be employed due to a “disability change of control termination” (as defined in the change of control agreement), then the severance payment will be prorated by a fraction, the numerator of which is the number of days elapsed from the date of the change of control (or the signing of an agreement, the consummation of which will result in a change of control, if such death or disability occurs prior to the actual change of control) through the date of termination, and the denominator of which is 365. Additionally, the vesting of outstanding equity awards will accelerate and the officer will be entitled to up to 12 months of post-termination benefits continuation under COBRA. Mr.Messrs. Katkin and Sibold and Dr. Kaye,Siffert, as senior executive officers, are entitled to severance payments equal to 24 months of base salary, while Ms. Ocampo is entitled to severance payments equal to 1218 months of base salary.

Severance Benefits without a Change of Control. The employment agreement with Mr. Katkin confers certain severance benefits even in the absence of a change of control. In the event Mr. Katkin is terminated without “cause” or he resigns for “good reason” (as such terms are defined) in the absence of a change of control, he will be eligible to receive severance benefits in an amount equal to one year of base salary, plus accelerated vesting of all outstanding equity awards.

Change of Control Provisions in Equity Plans. Under the Company’s 2003 and 2005 Equity Incentive Plans, in any change of control transaction (e.g., the acquisition of the Company by way of merger), if the successor corporation does not assume outstanding awards or issue substitute awards, then the vesting of such awards will accelerate so that they are fully exercisable. The Compensation Committee may also, in its discretion, elect to accelerate the vesting of any or all outstanding awards even if the successor corporation will assume such awards or provide for substitute awards. The vesting of certain options granted to non-employee directors under the 2005 Equity Incentive Plan will automatically accelerate immediately prior to any change of control transaction. Additionally, the 2005 Equity Incentive Plan provides that if a successor corporation assumes outstanding awards (or issues replacement awards) and the award holder is terminated without cause within 12 months following the change of control, then the vesting of awards then held by that person will automatically accelerate. In the event of a proposed dissolution or liquidation of the Company, the Board may cause awards granted under the 2003 and 2005 Equity Incentive Plans to be fully vested and exercisable (but not after their expiration date) before the dissolution is completed, but contingent on its completion.


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35


Potential Payments upon Termination or Change of Control

The table below shows the benefits potentially payable to each of our named executive officers if a change of control termination occurred on September 30, 2009.2011 (after giving effect to the compensation actions taken by the Compensation Committee in November 2011). The closing price per share of our common stock on The NASDAQ Global Market on September 30, 20092011 was $2.08.

                     
           Accelerated
    
        Accelerated
  Vesting of
    
  Base Salary
  Target Bonus
  Vesting of
  Restricted
  Total
 
Name
 ($)  ($)  Options(1)  Stock(2)  ($) 
 
Keith A. Katkin(3) $746,496  $235,146  $1,526,740  $858,491  $3,318,351 
Randall E. Kaye, M.D.(4) $653,334  $165,000  $574,862  $650,297  $2,009,160 
Christine G. Ocampo(5) $197,820  $75,963  $385,400  $119,600  $762,166 
$2.86.

   Base Salary   Bonus
Payment
   

Accelerated

Vesting of

   

Accelerated

Vesting of

Restricted

   Total 

Name

  ($)(1)   ($)   Options($)(2)   Stock($)(3)   ($) 

Keith A. Katkin (4)

  $1,011,432    $252,858    $1,112,067    $178,750    $2,555,107  

Joao Siffert, M.D. (5)

  $703,208    $105,000    $31,200    $—      $839,408  

Christine G. Ocampo (6)

  $336,843    $67,369    $318,315    $32,175    $754,702  

William J. Sibold (7)

  $700,000    $70,000    $—      $57,200    $827,200  

(1)Reflects potential payments based on salaries as of October 1, 2011.

(2)The value of the accelerated vesting equals the difference (if positive) between the option exercise price and the last reported stock price for fiscal 20092011 ($2.08)2.86), multiplied by the number of options that would have been accelerated upon a change of control occurring on September 30, 2009.2011.

(2)(3)The dollar value of restricted stock was calculated using the last reported stock price for fiscal 20092011 ($2.08)2.86).

(3)(4)Based on 1,307,6091,039,018 shares of underlying unvested stock options and 412,73662,500 shares of restricted stock outstanding as of September 30, 2009.2011.

(4)(5)Based on 429,780260,000 shares underlying unvested stock options outstanding as of September 30, 2011.

(6)Based on 263,562 shares underlying unvested stock options and 312,64311,250 shares of restricted stock outstanding as of September 30, 2009.2011.

(5)(7)Based 285,250 shares of underlying unvested stock options and 57,500on 20,000 shares of restricted stock outstanding as of September 30, 2009.2011.

The table below shows the benefits potentially payable to Mr. Katkin if his employment was terminated on September 30, 2009,2011 without cause or if he chose to resign for good reason in the absence of a change of control.

                     
           Accelerated
    
        Accelerated
  Vesting of
    
  Base Salary
  Target Bonus
  Vesting of
  Restricted
  Total(3)
 
Name
 ($)  ($)  Options(1)  Stock(2)  ($) 
 
Keith A. Katkin $373,248  $  $1,526,740  $858,491  $2,758,479 

   Base Salary   Bonus
Payment
   

Accelerated

Vesting of

   

Accelerated

Vesting of

Restricted

Stock

     

Name

  ($)   ($)   Options($)(1)   ($)(2)   Total($)(3) 

Keith A. Katkin

  $505,716     N/A    $1,112,067    $178,750    $1,796,533  

(1)The value of the accelerated vesting equals the difference (if positive) between the option exercise price and the last reported stock price for fiscal 20092011 ($2.08)2.86), multiplied by the number of options that would have been accelerated upon a termination without cause or a resignation for good reason occurring on September 30, 2009.2011.

(2)The dollar value of restricted stock was calculated using the last reported stock price for fiscal 20092011 ($2.08)2.86).

(3)Based on 1,307,6091,039,018 shares of underlying unvested stock options and 394,71662,500 shares of restricted stock outstanding as of September 30, 2009.2011.

401(k) Plan

We have established and maintain a retirement savings plan under Section 401(k) of the Internal Revenue Code. The Internal Revenue Code allows eligible employees to defer a portion of their compensation, within prescribed limits, on a tax deferred basis through contributions to a 401(k) plan. Our 401(k) plan permits us to make matching contributions on behalf of eligible employees, and we currently make these matching contributions up to a maximum amount of 50% of the first 4% of salary contributed to the plan per year. In fiscal 2009,2011, the total value of the Company’s matching contributions on behalf of the named executive officers was $10,261.

$7,861.


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36


DIRECTOR COMPENSATION

Non-Employee Director Compensation

A summary of the non-employee director compensation arrangements for fiscal 20102012 (effective October 1, 2009)2011) is set forth below.

     
  Retainer and
 
  Meeting Fees 
 
Annual Board Retainer Fee:
    
All non-employee directors $40,000 
Annual Chairman Retainer Fees:*
    
Chairman of the Board $25,000 
Audit Committee Chairman $25,000 
Compensation Committee Chairman $12,500 
Corporate Governance or Science Committee Chairman $10,000 
Annual Committee Member Retainer Fees:*
    
Audit Committee $10,000 
Compensation Committee $5,000 
Corporate Governance or Science Committee $3,750 

   Retainer and
Meeting Fees
 

Annual Board Retainer Fee:

  

All non-employee directors

  $40,000  

Annual Chairman Retainer Fees:*

  

Chairman of the Board

  $25,000  

Audit Committee Chairman

  $25,000  

Compensation Committee Chairman

  $15,000  

Corporate Governance or Science Committee Chairman

  $10,000  

Annual Committee Member Retainer Fees:*

  

Audit Committee

  $10,000  

Compensation Committee

  $7,500  

Corporate Governance or Science Committee

  $5,000  

*These fees are in addition to the Annual Board Retainer Fee, as applicable.

Non-employee directors are also reimbursed for their reasonableout-of-pocket expenses incurred in connection with attending Board and committee meetings and in attending continuing education seminars, to the extent that attendance is required by the Board or the committee(s) on which that director serves.

In fiscal 2009,2011, the Company awarded restricted stock units representing 60,00030,000 shares of common stock to each non-employee director, and 120,000except for Mr. Wheeler who received restricted stock units representing 35,000 shares of common stock to the Chairman of the Board.stock. These awards vest over one year. The total grant-date value of these awards to Messrs. Austin, Mathews and Podlesak and Drs. Mazzo and Whitcup was $163,800,$122,100, and the total grant-date value of the award to Mr. Wheeler was $142,450, based on a closing stock price of $0.39$4.07 on the NASDAQ Global Market on the date of grant.

The Compensation Committee and the Board will reassessreassesses the appropriate level of equity compensation for non-employee directors in fiscal 2010.on an annual basis. Future equity compensation payments will be determined on ayear-by-year basis for the foreseeable future due to the volatility of the Company’s stock price.

The following table shows the compensation paid in fiscal 20092011 to the Company’s non-employee directors.

                 
  Fees
          
  Earned or
          
  Paid in
  Stock
  Option
    
Name
 Cash  Awards(1)  Awards(1)  Total 
 
Stephen G. Austin(2) $52,500  $74,575  $  $127,075 
Charles A. Mathews(3) $45,000  $74,575  $  $119,575 
David J. Mazzo, Ph.D.(4) $42,188  $74,575  $  $116,763 
Dennis G. Podlesak(5) $36,563  $74,575  $  $111,138 
Nicholas J. Simon(6) $  $  $  $ 
Craig A. Wheeler(7) $59,063  $90,705  $  $149,768 
Scott M. Whitcup, M.D.(8) $40,313  $74,575  $1,877  $114,888 

Name and Principal Position

  Fees
Earned or
Paid in
Cash
   Stock
Awards(1)
   Total 

Stephen G. Austin

  $70,000    $122,100    $192,100  

Charles A. Mathews

  $60,000    $122,100    $182,100  

David J. Mazzo, Ph.D.

  $56,250    $122,100    $178,350  

Dennis G. Podlesak

  $48,750    $122,100    $170,850  

Craig A. Wheeler

  $78,750    $142,450    $221,200  

Scott M. Whitcup, M.D.

  $53,750    $122,100    $175,850  

(1)The value of the stock and option awards has been computed in accordance with SFAS No. 123(R), which requires that we recognize as compensation expenseFASB ASC 718, excluding the valueeffect of all stock-based awards granted to employees in exchange for services over the requisite service period, which is typically the vesting period, but excluding forfeiture assumptions that weestimated forfeitures. Assumptions used in calculating equity award expensethe calculations for these amounts are included in notes to our financial statements included in our Annual Report on Form 10-K for the Company’s financial statements.


27


Because compensation expense is recognized over the vesting period, which is typically three years, the figures in this table do not reflect the value of awards that were granted in any given fiscal year.
(2)Mr. Austin held 167,594 shares underlying restricted stock awards and 10,000 shares underlying outstanding option awards as ofyear ended September 30, 2009.
(3)Mr. Mathews held 167,594 shares underlying restricted stock awards and 15,000 shares underlying outstanding option awards as of September 30, 2009.
(4)Dr. Mazzo held 167,594 shares underlying restricted stock awards and 6,250 shares underlying outstanding option awards as of September 30, 2009.
(5)Mr. Podlesak held 167,594 shares underlying restricted stock awards and 6,250 shares underlying outstanding option awards as of September 30, 2009.
(6)Mr. Simon joined the Board in May 2008. To date, he has elected to forego any equity or cash compensation to which he would otherwise be entitled as a non-employee director.
(7)Mr. Wheeler held 227,594 shares underlying restricted stock awards and 6,250 shares underlying outstanding option awards as of September 30, 2009.
(8)Dr. Whitcup held 167,594 shares underlying restricted stock awards and 6,250 shares underlying outstanding option awards as of September 30, 2009.2011.


28

37


REPORT OF THE AUDIT COMMITTEE

The Audit Committee evaluates auditor performance, manages relations with the Company’s independent registered public accounting firm, and evaluates policies and procedures relating to internal control systems. The Audit Committee operates under a written Audit Committee Charter that has been adopted by the Board, a copy of which is available on the Company’s website atwww.Avanir.comwww.avanir.com. All members of the Audit Committee currently meet the independence and qualification standards for Audit Committee membership set forth in the listing standards provided by NASDAQ and the SEC.

Other than Mr. Austin, the Audit Committee members are not professional accountants or auditors. The members’ functions are not intended to duplicate or to certify the activities of management and the independent registered public accounting firm. The Audit Committee serves a board-level oversight role in which it provides advice, counsel and direction to management and the auditors on the basis of the information it receives, discussions with management and the auditors, and the experience of the Audit Committee’s members in business, financial and accounting matters.

The Audit Committee oversees the Company’s financial reporting process on behalf of the Board. The Company’s management has the primary responsibility for the financial statements and reporting process, including the Company’s system of internal controls. In fulfilling its oversight responsibilities, the Audit Committee reviewed with management the audited financial statements included in the Annual Report onForm 10-K for the fiscal year ended September 30, 2009.2011. This review included a discussion of the quality and the acceptability of the Company’s financial reporting, including the nature and extent of disclosures in the financial statements and the accompanying notes. The Audit Committee also reviewed the progress and results of the testing of the design and effectiveness of its internal controls over financial reporting pursuant to Section 404 of the Sarbanes-Oxley Act of 2002.

The Audit Committee also reviewed with the Company’s independent registered public accounting firm, which is responsible for expressing an opinion on the conformity of the audited financial statements with accounting principles generally accepted in the United States of America, their judgments as to the quality and the acceptability of the Company’s financial reporting and such other matters as are required to be discussed with the Committee under generally accepted auditing standards, including Statement on Auditing Standards No. 61, as amended (AICPA,Professional Standards, Vol. 1. AU section 380), as adopted by the Public Company Accounting Oversight Board in Rule 3200T. The Audit Committee has received the written disclosures and the letter from the independent registered public accounting firm required by the Public Company Accounting Oversight Board. The Audit Committee discussed with the independent registered public accounting firm their independence from management and the Company, including the matters required by the applicable rules of the Public Company Accounting Oversight Board.

In addition to the matters specified above, the Audit Committee discussed with the Company’s independent registered public accounting firm the overall scope, plans and estimated costs of their audit. The Committee met with the independent registered public accounting firm periodically, with and without management present, to discuss the results of the independent registered public accounting firm’s examinations, the overall quality of the Company’s financial reporting and the independent registered public accounting firm’s reviews of the quarterly financial statements, and drafts of the quarterly and annual reports.

In reliance on the reviews and discussions referred to above, the Audit Committee recommended to the Board of Directors that the Company’s audited financial statements should be included in the Company’s Annual Report onForm 10-K for the fiscal year ended September 30, 2009.

2011.

Submitted by the Audit Committee of the Board of Directors

Stephen G. Austin, Chairman

Stephen G. Austin, Chairman

Charles A. Mathews

Craig A. Wheeler


29

38


OTHER BUSINESS

We know of no other matters to be submitted to a vote of stockholders at the annual meeting. If any other matter is properly brought before the annual meeting or any adjournment thereof, it is the intention of the persons named in the enclosed proxy to vote the shares they represent in accordance with their judgment. In order for any stockholder to nominate a candidate or to submit a proposal for other business to be acted upon at a given annual meeting, he or she must provide timely written notice to our corporate secretary in the form prescribed by our Bylaws, as described below.

STOCKHOLDER PROPOSALS

Stockholder proposals intended to be included in next year’sthe 2013 annual meeting proxy materials must be received by the Secretary of the Company no later than September 10, 20105, 2012, or otherwise as permitted by applicable law (theProxy Deadline”Deadline). The form and substance of these proposals must satisfy the requirements established by the Company’s Bylaws and the SEC, and the timing for the submission of any such proposals may be subject to change as a result of changes in SEC rules and regulations.

Additionally, stockholders who intend to present a stockholder proposal at the 20112013 annual meeting must provide the Secretary of the Company with written notice of the proposal between 90 and 120 days prior to the date of the annual meeting,provided, however, that if the 20112013 annual meeting date is advanced by more than 30 days before or delayed by more than 60 days after the anniversary date of the 20102012 annual meeting, then stockholders must provide notice within time periods specified in our Bylaws. Notice must be tendered in the proper form prescribed by our Bylaws. Proposals not meeting the requirements set forth in our Bylaws will not be entertained at the meeting.

Additionally, any stockholder seeking to recommend a director candidate or any director candidate who wishes to be considered by the Corporate Governance Committee, the committee that recommends a slate of nominees to the Board for election at each annual meeting, must provide the Secretary of the Company with a completed and signed biographical questionnaire on or before the Proxy Deadline. Stockholders can obtain a copy of this questionnaire from the Secretary of the Company upon written request. The Corporate Governance Committee is not required to consider director candidates received after this date or without the required questionnaire. The Corporate Governance Committee will consider all director candidates who comply with these requirements and will evaluate these candidates using the criteria described above under the caption, “Nomination of Directors.” Director candidates who are then approved by the Board will be included in the Company’s proxy statement for that annual meeting.

39


Delivery of Proxy MaterialsDELIVERY OF PROXY MATERIALS

Our annual report to stockholders for the fiscal year ended September 30, 2009,2011, including audited financial statements, accompanies this Proxy Statement. Copies of our Annual Report onForm 10-K for fiscal 20092011 and the exhibits thereto are available from the Company without charge upon written request of a stockholder. Copies of these materials are also available online through the Securities and Exchange Commission atwww.sec.gov. The Company may satisfy SEC rules regarding delivery of proxy materials, including the proxy statement, annual report and Notice, by delivering a single Notice and, if applicable, a single set of proxy materials to an address shared by two or more Company stockholders. This delivery method can result in meaningful cost savings for the Company. In order to take advantage of this opportunity, the Company may deliver only one Notice and, if applicable, a single set of proxy materials to multiple stockholders who share an address, unless contrary instructions are received prior to the mailing date. Similarly, if you share an address with another stockholder and have received multiple copies of our Noticeand/or other proxy materials, you may write or call us at the address and phone number below to request delivery of a single copy of the Notice and, if applicable, other proxy materials in the future. We undertake to deliver promptly upon written or oral request a separate copy of the Notice and, if applicable, other proxy materials, as requested, to a stockholder at a shared address to which a single copy of the Noticeand/or other proxy materials was delivered. If you hold stock as a record stockholder and prefer to receive separate copies of a Notice and, if applicable, other proxy materials either now or in the future, please contact the Company’s investor relations department at 10120 Enterprise, Suite 300,200, Aliso Viejo California 92656 or by telephone at(949) 389-6700. If your stock is held through a brokerage firm or bank and you prefer to receive separate copies of a Notice and, if applicable, other proxy materials either now or in the future, please contact your brokerage firm or bank.

EACH STOCKHOLDER IS URGED TO COMPLETE, DATE, SIGN AND PROMPTLY RETURN

THE ENCLOSED PROXY.


30

40


(AVANIR LOGO)
AVANIR PHARMACEUTICALS, INC.
101 ENTERPRISE, SUITE 300
ALISO VIEJO, CA 92656
VOTE BY INTERNET - www.proxyvote.com
Use the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59 P.M. Eastern Time the day before the cut-off date or meeting date. Have your proxy card in hand when you access the web site and follow the instructions to obtain your records and to create an electronic voting instruction form.
Electronic Delivery of Future PROXY MATERIALS
If you would like to reduce the costs incurred by our company in mailing proxy materials, you can consent to receiving all future proxy statements, proxy cards and annual reports electronically via e-mail or the Internet. To sign up for electronic delivery, please follow the instructions above to vote using the Internet and, when prompted, indicate that you agree to receive or access proxy materials electronically in future years.
VOTE BY PHONE - 1-800-690-6903
Use any touch-tone telephone to transmit your voting instructions up until 11:59 P.M. Eastern Time the day before the cut-off date or meeting date. Have your proxy card in hand when you call and then follow the instructions.
VOTE BY MAIL
Mark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717.


LOGO

AVANIR PHARMACEUTICALS, INC.

20 ENTERPRISE, SUITE 200

ALISO VIEJO, CA 92656

  

VOTE BY INTERNET -www.proxyvote.com

Use the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59 p.m. Eastern Time the day before the cut-off date or meeting date. Have your proxy card in hand when you access the web site and follow the instructions to obtain your records and to create an electronic voting instruction form.

ELECTRONIC DELIVERY OF FUTURE PROXY MATERIALS

If you would like to reduce the costs incurred by our company in mailing proxy materials, you can consent to receiving all future proxy statements, proxy cards and annual reports electronically via e-mail or the Internet. To sign up for electronic delivery, please follow the instructions above to vote using the Internet and, when prompted, indicate that you agree to receive or access proxy materials electronically in future years.

VOTE BY PHONE - 1-800-690-6903

Use any touch-tone telephone to transmit your voting instructions up until 11:59 p.m. Eastern Time the day before the cut-off date or meeting date. Have your proxy card in hand when you call and then follow the instructions.

VOTE BY MAIL

Mark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717.

TO VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS FOLLOWS:

M39431-P17933 KEEP THIS PORTION FOR YOUR RECORDS
  
THIS PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED. DETACH AND RETURN THIS PORTION ONLY
  

THIS PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED.

(REG NO.)

                   
  For
All
 Withhold
All
 For All
Except
 To withhold authority to vote for any
individual nominee(s), mark “For All
Except” and write the number(s) of the
nominee(s) on the line below.
    
The Board of Directors recommends that you vote FOR the following:
       
   0   0   0      

AVANIR PHARMACEUTICALS, INC.

 For All Withhold AllFor All Except

To withhold authority to vote for any individual nominee(s), mark “For All Except” and write the number(s) of the nominee(s) on the line below.

The Board of Directors recommends that you

vote FOR the following:

     

      Vote on Directors

¨¨¨

1.

 Election of Directors  
Nominees:
01) Keith A. Katkin
02) Charles A. Mathews
Vote on Proposals

The Board of Directors recommends you vote FOR the following proposals:

ForAgainstAbstain

2.

Ratification of KMJ Corbin & Company, LLP as independent registered public accounting firm for the fiscal year ending September 30, 2012.¨¨¨

3.

Advisory (non-binding) vote on the Company’s executive compensation.¨¨¨

For address changes and/or comments, please check this box and write them on the back where indicated.¨
Please indicate if you plan to attend this meeting.¨¨    
YesNo

Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Joint owners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name, by authorized officer.

   Nominees  
      
01David J. Mazzo, Ph.D.02 Craig A. Wheeler03 Scott M. Whitcup, M.D.
               
The Board of Directors recommends you vote FOR the following proposal(s): For Against Abstain
 
2 Ratification of KMJ Corbin & Company, LLP as independent registered public accounting firm for the fiscal year ending September 30, 2010.  0   0   0 
NOTE:Transaction of any other business that may properly come before the meeting or any adjournment or adjournments thereof.
             
For address change/comments, mark here.          0 
(see reverse for instructions) Yes No    
Please indicate if you plan to attend this meeting  0   0     
Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Joint owners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name, by authorized officer.
     

Signature [PLEASE SIGN WITHIN BOX]
Date
 Date 
Signature (Joint Owners)  

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Signature (Joint Owners)

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Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting:

The Notice &and Proxy Statement and Form 10-K is/are available atwww.proxyvote.com.

(REG NO.)

M39432-P17933

AVANIR PHARMACEUTICALS, INC.

Annual Meeting of Stockholders

February 18, 201016, 2012 9:00 AM

This proxy is solicited by the Board of Directors

The stockholder(s) hereby appoint(s) Keith A. Katkin and Christine G. Ocampo, or either of them, as proxies, each with the power to appoint his or her substitute, and hereby authorize(s) them to represent and to vote, as designated on the reverse side of this ballot, all of the shares of Common Stock of Avanir Pharmaceuticals, Inc. that the stockholder(s) is/are entitled to vote at the 20102012 Annual Meeting of Stockholders to be held at 9:00 a.m. Pacific Time on February 18, 201016, 2012 at the IslandRenaissance Club Sport Aliso Viejo Hotel, located at 690 Newport Center Drive, Newport Beach,50 Enterprise, Aliso Viejo, California, and at any adjournment or postponement thereof.

This proxy, when properly executed, will be voted in the manner directed herein. If no such direction is made, this proxy will be voted in accordance with the Board of Directors’ recommendations.

Address change/comments:
recommendations and in the discretion of the proxy holders on all other matters that may come before the meeting.

   
  Address Changes/Comments:
   
  
   
   

(If you noted any Address Changes and/or Changes/Comments above, please mark corresponding box on the reverse side.)

Continued and to be signed on reverse side